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    Tekt2 tektin 2 [ Mus musculus (house mouse) ]

    Gene ID: 24084, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tekt2provided by MGI
    Official Full Name
    tektin 2provided by MGI
    Primary source
    MGI:MGI:1346335
    See related
    Ensembl:ENSMUSG00000028845 AllianceGenome:MGI:1346335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tektin-t
    Summary
    Involved in flagellated sperm motility. Acts upstream of or within inner dynein arm assembly. Located in microtubule organizing center. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in foregut-midgut junction and inner ear. Orthologous to human TEKT2 (tektin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 147.5) and limb E14.5 (RPKM 8.4) See more
    Orthologs
    NEW
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    Genomic context

    See Tekt2 in Genome Data Viewer
    Location:
    4 D2.2; 4 60.37 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126215914..126219481, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126322121..126325688, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene collagen, type VIII, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125998967-125999150 Neighboring gene ADP-ribosylserine hydrolase Neighboring gene STARR-seq mESC enhancer starr_11400 Neighboring gene argonaute RISC catalytic subunit 3 Neighboring gene STARR-seq mESC enhancer starr_11401 Neighboring gene STARR-positive B cell enhancer ABC_E7988 Neighboring gene argonaute RISC catalytic subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11403 Neighboring gene STARR-positive B cell enhancer ABC_E2714

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tektin-2
    Names
    testicular tektin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357262.1NP_001344191.1  tektin-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK006205, AL606976, BG083070, BY084876, BY094167
      Consensus CDS
      CCDS18651.1
      UniProtKB/Swiss-Prot
      Q922G7, Q9WVR0
      Related
      ENSMUSP00000099676.2, ENSMUST00000102616.8
      Conserved Domains (1) summary
      pfam03148
      Location:17395
      Tektin; Tektin family
    2. NM_001357263.1NP_001344192.1  tektin-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK006205, AL606976, BB603783, BG083070, BY084876, BY094167
      Consensus CDS
      CCDS18651.1
      UniProtKB/Swiss-Prot
      Q922G7, Q9WVR0
      Conserved Domains (1) summary
      pfam03148
      Location:17395
      Tektin; Tektin family
    3. NM_011902.3NP_036032.2  tektin-2

      See identical proteins and their annotated locations for NP_036032.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) reprsents the longest transcript. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK006205, AL606976, BG083070, BY084876, BY094167
      Consensus CDS
      CCDS18651.1
      UniProtKB/Swiss-Prot
      Q922G7, Q9WVR0
      Conserved Domains (1) summary
      pfam03148
      Location:17395
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126215914..126219481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)