Dpep1 dipeptidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpep1provided by MGI
Official Full Name: dipeptidase 1provided by MGI
Primary source: MGI:MGI:94917
See related: Ensembl:ENSMUSG00000019278 AllianceGenome:MGI:94917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBD; DPEP-1
Summary: Enables beta-lactamase activity and dipeptidase activity. Involved in several processes, including glutathione catabolic process; leukotriene metabolic process; and neutrophil chemotaxis. Predicted to be located in several cellular components, including apical part of cell; extracellular space; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in genitourinary system; incisor; and lung. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to human DPEP1 (dipeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 182.7), small intestine adult (RPKM 109.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 72.08 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123913069..123928551)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (123186235..123201812)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.
Title: Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.
Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
Title: Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
Title: A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
Genetic ablation or functional peptide blocking of DPEP1 significantly reduced neutrophil recruitment to the lungs and liver and provided improved survival in models of endotoxemia.
Title: Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver.
Contrast-induced acute kidney injury is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1.
Title: Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI327012 (e-PCR)
- UniSTS:159833

D13139 (e-PCR)
- UniSTS:163449

ha2335 (e-PCR)
- UniSTS:515528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GPI anchor binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-lactamase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-lactamase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallodipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables modified amino acid binding	ISO Inferred from Sequence Orthology more info
enables modified amino acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in antibiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in antibiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in antibiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nitric oxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homocysteine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in homocysteine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene D4 catabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene D4 catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukotriene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dipeptidase 1

Names: MBD-1; beta-lactamase; dipeptidase 1 (renal); membrane bound dipeptidase type II; membrane-bound dipeptidase 1; microsomal dipeptidase; renal dipeptidase

NP_001403941.1

EC 3.4.13.19

EC 3.5.2.6

NP_031902.2

EC 3.4.13.19

EC 3.5.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417012.1 → NP_001403941.1 dipeptidase 1 precursor

Status: VALIDATED

Source sequence(s)

AC163617

UniProtKB/Swiss-Prot

G5E824, P31428

UniProtKB/TrEMBL

Q99LA8
NM_007876.3 → NP_031902.2 dipeptidase 1 precursor

See identical proteins and their annotated locations for NP_031902.2

Status: VALIDATED

Source sequence(s)

AC163617

Consensus CDS

CCDS22750.1

UniProtKB/Swiss-Prot

G5E824, P31428

UniProtKB/TrEMBL

Q99LA8

Related

ENSMUSP00000019422.5, ENSMUST00000019422.6

Conserved Domains (1) summary

pfam01244
Location:25 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)