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    Or4e1 olfactory receptor family 4 subfamily E member 1 [ Mus musculus (house mouse) ]

    Gene ID: 57270, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Or4e1provided by MGI
    Official Full Name
    olfactory receptor family 4 subfamily E member 1provided by MGI
    Primary source
    MGI:MGI:3031342
    See related
    Ensembl:ENSMUSG00000057564 AllianceGenome:MGI:3031342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Or10; Mor10; MOR244-2; MOR244-4; Olfr1508
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Or4e1 in Genome Data Viewer
    Location:
    14 C2; 14 26.95 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52700178..52704918, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52462721..52467461, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha variable 1 Neighboring gene olfactory receptor family 4 subfamily E member 2 Neighboring gene T cell receptor alpha chain Neighboring gene predicted gene, 36382 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene olfactory receptor family 4 subfamily E member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutually exclusive expression of odorant receptor transgenes. Serizawa S, et al. Nat Neurosci, 2000 Jul. PMID 10862701
    2. Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Serizawa S, et al. Science, 2003 Dec 19. PMID 14593185
    3. Olfactory neurons expressing closely linked and homologous odorant receptor genes tend to project their axons to neighboring glomeruli on the olfactory bulb. Tsuboi A, et al. J Neurosci, 1999 Oct 1. PMID 10493742, Free PMC Article
    4. Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb. Takeuchi H, et al. Cell, 2010 Jun 11. PMID 20550939
    5. Emx2 stimulates odorant receptor gene expression. McIntyre JC, et al. Chem Senses, 2008 Nov. PMID 18854508, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    odorant receptor MOR10
    Names
    GA_x6K02T2RJGY-520647-521579
    gene for odorant receptor MOR10
    olfactory receptor 1508
    olfactory receptor MOR244-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007044.1 

      Range
      35255..39995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020513.3 → NP_065259.1  odorant receptor MOR10

      See identical proteins and their annotated locations for NP_065259.1

      Status: VALIDATED

      Source sequence(s)
      AC126025
      Consensus CDS
      CCDS27061.1
      UniProtKB/TrEMBL
      Q9R0K4
      Related
      ENSMUSP00000145649.2, ENSMUST00000206520.3
      Conserved Domains (2) summary
      pfam00001
      Location:44 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52700178..52704918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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