Dner delta/notch-like EGF repeat containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnerprovided by MGI
Official Full Name: delta/notch-like EGF repeat containingprovided by MGI
Primary source: MGI:MGI:2152889
See related: Ensembl:ENSMUSG00000036766 AllianceGenome:MGI:2152889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BET; Bret; A930026D19Rik
Summary: Enables Notch binding activity. Acts upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Located in dendrite and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; limb; peripheral nervous system ganglion; and sensory organ. Orthologous to human DNER (delta/notch like EGF repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 74.8), CNS E18 (RPKM 57.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.4 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (84347560..84673942, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (84369839..84696221, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.
Title: Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.
Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.
Title: Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis.
Title: BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis.
Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating Hippo pathway.
Title: Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating Hippo pathway.
this study shows that BET inhibition modifies melanoma infiltrating T cells and enhances response to PD-L1 blockade
Title: BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade.
DNER is a novel protein induced in COPD patients and 6months CS-exposed mice that regulates IFNgamma secretion via non-canonical Notch in pro-inflammatory recruited macrophages.
Title: The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.
Overall, these studies show that BET proteins may have a critical role in asthma pathogenesis by altering type 17 inflammation.
Title: Bromodomain and Extra-Terminal Protein Inhibition Attenuates Neutrophil-dominant Allergic Airway Disease.
This study showed that the DNER is present in ganglion and amacrine cells on P1, also labeling the horizontal cells by P10. Developing AII amacrine cells exhibit accumulating DNER labeling at the dendritic stalk, labeling that becomes progressively conspicuous by P10, as it is in maturity.
Title: DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina.
the present study demonstrated that DNER was expressed in SGNs and appeared to be involved in the mechanisms underlying neuronal polarity and neuritogenesis, via a Notchdependent signaling pathway.
Title: DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway.
DNER plays a redundant role with other Notch ligands in cochlear development
Title: Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit438 (e-PCR), detects polymorphism
- UniSTS:128806

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch receptor processing	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: delta and Notch-like epidermal growth factor-related receptor

Names: brain EGF repeat-containing transmembrane protein; delta/notch-like EGF-related receptor; transmembrane protein Bet

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152915.1 → NP_690879.1 delta and Notch-like epidermal growth factor-related receptor precursor

See identical proteins and their annotated locations for NP_690879.1

Status: PROVISIONAL

Source sequence(s)

BC034634

Consensus CDS

CCDS15105.1

UniProtKB/Swiss-Prot

Q3U697, Q8JZM4, Q8R226, Q8R4T6, Q8VD97

Related

ENSMUSP00000042927.7, ENSMUST00000049126.13

Conserved Domains (1) summary

cd00054
Location:581 → 617

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...