INSL5 insulin like 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: INSL5provided by HGNC
Official Full Name: insulin like 5provided by HGNC
Primary source: HGNC:HGNC:6088
See related: Ensembl:ENSG00000172410 MIM:606413; AllianceGenome:HGNC:6088
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRO182; UNQ156
Summary: The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward colon (RPKM 81.8) See more
Orthologs: mouse all
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Genomic context

Location:: 1p31.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (66797740..66801276, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (66675282..66678818, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (67263423..67266959, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insulin-like peptide 5 is associated with insulin resistance in women with polycystic ovary syndrome.
Title: Insulin-like peptide 5 is associated with insulin resistance in women with polycystic ovary syndrome.
Insulin-like peptide 5 (INSL5) positively correlates with anti-Mullerian hormone (AMH) in women with the polycystic ovary syndrome: a case-control study.
Title: Insulin-like peptide 5 (INSL5) positively correlates with anti-Müllerian hormone (AMH) in women with the polycystic ovary syndrome: a case-control study.
Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn's Disease.
Title: Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn's Disease.
Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.
Title: Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.
This study provides novel insights into possible autocrine/paracrine roles of INSL5 in the intestinal tract.
Title: INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.
High serum INLS5 levels are associated with metabolic diseases in women with polycystic ovary syndrome.
Title: Circulating insulin-like peptide 5 levels and its association with metabolic and hormonal parameters in women with polycystic ovary syndrome.
The R27S (B5Ser) mutant variant of INSL5 was evaluated as a potential antagonist of the native RXFP4 receptor, yet was found to match the potency and maximal efficacy to the native hormone. This informs that the R27S phenotype is not directly linked to the receptor activity of the peptide, but likely affects endogenous hormone production or secretion.
Title: Synthesis and Characterization of the R27S Genetic Variant of Insulin-like Peptide 5.
Mass spectral analysis of purified enteroendocrine cells and tissue homogenates identified the exact sequence of A and B chains of INSL5 endogenously expressed in L-cells.
Title: Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.
analysis of the interaction mechanism of INSL5 with its receptor RXFP4
Title: Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.
High serum INSL5 is associated with obesity in men.
Title: Insulin-Like Peptide 5 Interacts with Sex Hormones and Metabolic Parameters in a Gender and Adiposity Dependent Manner in Humans.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

INSL5__6469 (e-PCR)
- UniSTS:464502

NoName (e-PCR)
- UniSTS:485819

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info

General protein information

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Preferred Names: insulin-like peptide INSL5

Names: insulin-like peptide 5; prepro-INSL5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005478.6 → NP_005469.2 insulin-like peptide INSL5 precursor

See identical proteins and their annotated locations for NP_005469.2

Status: REVIEWED

Source sequence(s)

AL354978

Consensus CDS

CCDS634.1

UniProtKB/Swiss-Prot

Q3MIY4, Q5VYD8, Q9Y5Q6

Related

ENSP00000302724.2, ENST00000304526.3

Conserved Domains (1) summary

cd04365
Location:25 → 135

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...