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    RFC2 replication factor C subunit 2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853531, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RFC2
    Official Full Name
    replication factor C subunit 2
    Primary source
    SGD:S000003829
    Locus tag
    YJR068W
    See related
    AllianceGenome:SGD:S000003829; FungiDB:YJR068W; VEuPathDB:YJR068W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA clamp loader activity. Involved in DNA replication checkpoint signaling; leading strand elongation; and sister chromatid cohesion. Located in nucleus. Part of chromosome. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RFC2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (567643..568704)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol kinase-related protein kinase TOR1 Neighboring gene Yae1p Neighboring gene nucleoside triphosphate pyrophosphohydrolase HAM1 Neighboring gene deoxyhypusine monooxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RFC2 gene encoding a subunit of replication factor C of Saccharomyces cerevisiae. Noskov V, et al. Nucleic Acids Res, 1994 May 11. PMID 8202350, Free PMC Article
    2. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Kim HS, et al. Mol Cell Biol, 2001 Jun. PMID 11340166, Free PMC Article
    3. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways. Shimomura T, et al. Mol Cell Biol, 1998 Sep. PMID 9710632, Free PMC Article
    4. Eukaryotic DNA mismatch repair. Kolodner RD, et al. Curr Opin Genet Dev, 1999 Feb. PMID 10072354
    5. Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants. Amin NS, et al. Genetics, 1999 Dec. PMID 10581271, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA clamp unloading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA strand elongation involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mismatch repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Elg1 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Elg1 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 2
    NP_012602.3
    • Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      567643..568704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181726.3 → NP_012602.3  TPA: replication factor C subunit 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012602.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWN9, E9P8U1, P40348
      UniProtKB/TrEMBL
      A6ZQ27, C7GMD5, C8ZBL6, G2WH73, N1P1L7
      Conserved Domains (1) summary
      PRK00440
      Location:23 → 353
      rfc; replication factor C small subunit; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40348.1

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