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    Wls wntless WNT ligand secretion mediator [ Mus musculus (house mouse) ]

    Gene ID: 68151, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wlsprovided by MGI
    Official Full Name
    wntless WNT ligand secretion mediatorprovided by MGI
    Primary source
    MGI:MGI:1915401
    See related
    Ensembl:ENSMUSG00000028173 AllianceGenome:MGI:1915401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EVI; Gpr177; 5031439A09Rik
    Summary
    Enables Wnt-protein binding activity. Involved in several processes, including brain development; cementum mineralization; and exocrine pancreas development. Acts upstream of or within Wnt protein secretion. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skin. Used to study Zaki syndrome. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 41.9), limb E14.5 (RPKM 30.9) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Wls in Genome Data Viewer
    Location:
    3 H4; 3 82.65 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (159545287..159644302)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (159839650..159938666)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:159158158-159158459 Neighboring gene DEP domain containing 1a Neighboring gene retinal pigment epithelium 65 Neighboring gene STARR-seq mESC enhancer starr_09398 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:159503248-159503357 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) pseudogene Neighboring gene calponin 2 pseudogene Neighboring gene predicted gene, 23941

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mu-type opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mu-type opioid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Wnt protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cementum mineralization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt protein secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein wntless homolog
    Names
    G protein-coupled receptor 177
    integral membrane protein GPR177
    protein evenness interrupted homolog
    wntless homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356349.1NP_001343278.1  protein wntless homolog isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC121906, AC225719, AK019886, BQ179316
      Conserved Domains (1) summary
      pfam06664
      Location:78396
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
    2. NM_001356350.1NP_001343279.1  protein wntless homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121906, AC175245, AC225719, AK044810
      Consensus CDS
      CCDS38684.1
      UniProtKB/Swiss-Prot
      Q6DID7, Q8CE42, Q9D2B7
      Related
      ENSMUSP00000143475.2, ENSMUST00000198878.2
      Conserved Domains (1) summary
      pfam06664
      Location:178496
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
    3. NM_026582.5NP_080858.3  protein wntless homolog isoform 1

      See identical proteins and their annotated locations for NP_080858.3

      Status: VALIDATED

      Source sequence(s)
      AC121906, AC225719, BC075615
      Consensus CDS
      CCDS38684.1
      UniProtKB/Swiss-Prot
      Q6DID7, Q8CE42, Q9D2B7
      Related
      ENSMUSP00000067898.6, ENSMUST00000068952.10
      Conserved Domains (1) summary
      pfam06664
      Location:178496
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      159545287..159644302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)