Gprc5b G protein-coupled receptor, family C, group 5, member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gprc5bprovided by MGI
Official Full Name: G protein-coupled receptor, family C, group 5, member Bprovided by MGI
Primary source: MGI:MGI:1927596
See related: Ensembl:ENSMUSG00000008734 AllianceGenome:MGI:1927596
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Raig2
Summary: Enables protein kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of neuron differentiation; and positive regulation of signal transduction. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of neuron projection development; and positive regulation of protein kinase activity. Located in cell surface. Is active in membrane raft. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 63.2), frontal lobe adult (RPKM 44.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 63.72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (118571263..118594434, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (118972040..118995211, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development.
Title: Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development.
The orphan receptor GPRC5B activates pro-inflammatory signaling in the vascular wall via Fyn and NFkappaB.
Title: The orphan receptor GPRC5B activates pro-inflammatory signaling in the vascular wall via Fyn and NFκB.
GPRC5B promotes collagen production in myofibroblasts.
Title: GPRC5B promotes collagen production in myofibroblasts.
GPRC5b is a novel podocyte-specific receptor that regulates inflammatory response in the glomerulus bymodulating the NF-kB signaling pathway.
Title: GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway.
In Gprc5b(-/-) mice, long-term motor learning was impaired in both the rotarod test and the horizontal optokinetic response eye movement (HOKR) test
Title: Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning.
The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex.
Title: The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex.
GPRC5B activates obesity-associated inflammatory signaling in adipocytes.
Title: GPRC5B activates obesity-associated inflammatory signaling in adipocytes.
GPRC5B has important roles for animal behavior controlled by the central nervous system.
Title: Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.
Gprc5b-v2 may play a role during brain maturation and in matured brain, possibly through the regulation of neuronal morphology and protein-protein interaction
Title: A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons.
GPRC5B is involved in retinoic acid -dependent morphogenesis/angiogenesis and regulation of extracellular matrix synthesis in the murine placenta and yolk sac.
Title: Changes in expression and localization of GPRC5B and RARalpha in the placenta and yolk sac during middle to late gestation in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

General gene information

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Markers

RH137212 (e-PCR)
- UniSTS:219300

AW125761 (e-PCR)
- UniSTS:179635

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase inhibitor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell volume homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular exosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor family C group 5 member B

Names: RAIG-2; hypothetical protein, clone 2-63; retinoic acid-induced gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195774.1 → NP_001182703.1 G-protein coupled receptor family C group 5 member B isoform 1 precursor

See identical proteins and their annotated locations for NP_001182703.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC151534, CJ054496, FJ529379

Consensus CDS

CCDS85400.1

UniProtKB/TrEMBL

D2DFA9

Related

ENSMUSP00000146777.2, ENSMUST00000208394.2

Conserved Domains (1) summary

pfam00003
Location:112 → 293

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
NM_022420.2 → NP_071865.1 G-protein coupled receptor family C group 5 member B isoform 2 precursor

See identical proteins and their annotated locations for NP_071865.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC151534

Consensus CDS

CCDS21777.1

UniProtKB/Swiss-Prot

Q8CCV3, Q923Z0

Related

ENSMUSP00000008878.9, ENSMUST00000008878.10

Conserved Domains (1) summary

pfam00003
Location:112 → 293

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR