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    Dynlrb2 dynein light chain roadblock-type 2 [ Mus musculus (house mouse) ]

    Gene ID: 75465, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dynlrb2provided by MGI
    Official Full Name
    dynein light chain roadblock-type 2provided by MGI
    Primary source
    MGI:MGI:1922715
    See related
    Ensembl:ENSMUSG00000034467 AllianceGenome:MGI:1922715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DNLC2B; Dncl2b; 1700009A04Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Part of cytoplasmic dynein complex. Is expressed in several structures, including brain ventricle and choroid plexus; lung; palatal shelf mesenchyme; and sensory organ. Orthologous to human DYNLRB2 (dynein light chain roadblock-type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 68.2), lung adult (RPKM 17.8) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Dynlrb2 in Genome Data Viewer
    Location:
    8 E1; 8 63.07 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117231754..117242654)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (116505015..116515915)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:119028691-119028992 Neighboring gene NDC80 homolog, kinetochore complex component pseudogene Neighboring gene STARR-seq mESC enhancer starr_22798 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 39258 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119111671-119111780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114162-119114494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114548-119114808 Neighboring gene chromodomain protein, Y chromosome-like 2 Neighboring gene predicted gene, 31367

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynein light chain roadblock-type 2
    Names
    dynein light chain 2B, cytoplasmic
    dynein, cytoplasmic, light chain 2B
    dynein, cytoplasmic, light polypeptide 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029297.1NP_083573.1  dynein light chain roadblock-type 2

      See identical proteins and their annotated locations for NP_083573.1

      Status: PROVISIONAL

      Source sequence(s)
      AK005789
      Consensus CDS
      CCDS40487.1
      UniProtKB/Swiss-Prot
      Q9DAJ5
      Related
      ENSMUSP00000077301.6, ENSMUST00000078170.7
      Conserved Domains (1) summary
      pfam03259
      Location:393
      Robl_LC7; Roadblock/LC7 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      117231754..117242654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)