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    Duxf3 double homeobox family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 74399, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Duxf3provided by MGI
    Official Full Name
    double homeobox family member 3provided by MGI
    Primary source
    MGI:MGI:1921649
    See related
    Ensembl:ENSMUSG00000075046 AllianceGenome:MGI:1921649
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933403O03Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Duxf3 in Genome Data Viewer
    Location:
    10 B4; 10 29.29 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58064887..58070140, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58229505..58233089, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene double homeobox protein 4-like protein 2 Neighboring gene double homeobox family member 2 Neighboring gene double homeobox family member 4 Neighboring gene double homeobox family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos. Xu R, et al. Cell Stem Cell, 2022 Jul 7. PMID 35803226
    2. Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Yang G, et al. Cell Stem Cell, 2021 Jan 7. PMID 33049217
    3. Precise temporal regulation of Dux is important for embryo development. Guo M, et al. Cell Res, 2019 Nov. PMID 31591446, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    double homeobox protein 4-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      58064887..58070140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245412.2 → XP_030101272.1  double homeobox protein 4-like protein 2

      UniProtKB/TrEMBL
      A0A0N4SV92, A1JVI6, A1JVI7
      Related
      ENSMUSP00000145004.2, ENSMUST00000176875.4
      Conserved Domains (2) summary
      smart00389
      Location:112 → 162
      HOX; Homeodomain
      cd00086
      Location:19 → 73
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033485.1: Suppressed sequence

      Description
      NR_033485.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials