U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tbpl1 TATA box binding protein-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 237336, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tbpl1provided by MGI
    Official Full Name
    TATA box binding protein-like 1provided by MGI
    Primary source
    MGI:MGI:1339946
    See related
    Ensembl:ENSMUSG00000071359 AllianceGenome:MGI:1339946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    STD; TLF; TRP; Tlp; TRF2; 4732475G08
    Summary
    Predicted to enable RNA polymerase II core promoter sequence-specific DNA binding activity and RNA polymerase II general transcription initiation factor activity. Acts upstream of or within acrosome assembly; dTTP biosynthetic process; and spermatid nucleus differentiation. Located in cytoplasm and male germ cell nucleus. Part of transcription factor TFIIA complex. Is expressed in several structures, including central nervous system; early conceptus; ganglia; gonad; and sensory organ. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 19.3), CNS E14 (RPKM 9.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tbpl1 in Genome Data Viewer
    Location:
    10 A3; 10 10.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22579776..22607882, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (22703877..22732666, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26019 Neighboring gene STARR-seq mESC enhancer starr_26020 Neighboring gene STARR-seq mESC enhancer starr_26021 Neighboring gene predicted gene, 40610 Neighboring gene STARR-seq mESC enhancer starr_26022 Neighboring gene STARR-seq mESC enhancer starr_26023 Neighboring gene STARR-seq mESC enhancer starr_26024 Neighboring gene STARR-seq mESC enhancer starr_26025 Neighboring gene predicted gene, 40612 Neighboring gene STARR-seq mESC enhancer starr_26026 Neighboring gene predicted gene, 46216 Neighboring gene STARR-seq mESC enhancer starr_26029 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 12 Neighboring gene STARR-seq mESC enhancer starr_26030 Neighboring gene microRNA 7663 Neighboring gene STARR-seq mESC enhancer starr_26034 Neighboring gene STARR-seq mESC enhancer starr_26035 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 10824 Neighboring gene transcription factor 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIIA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    TATA box-binding protein-like 1
    Names
    21 kDa TBP-like protein
    TATA box binding protein-like protein
    TATA box-binding protein-like protein 1
    TATA box-binding protein-related factor 2
    TBP-like 1
    TBP-like factor
    TBP-like protein 1
    TBP-related factor 2
    TBP-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421603.1NP_001408532.1  TATA box-binding protein-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166256
    2. NM_001421604.1NP_001408533.1  TATA box-binding protein-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166256
      UniProtKB/Swiss-Prot
      P62340
      UniProtKB/TrEMBL
      Q8K073
    3. NM_001421605.1NP_001408534.1  TATA box-binding protein-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166256
      UniProtKB/Swiss-Prot
      P62340
      UniProtKB/TrEMBL
      Q8K073
      Related
      ENSMUSP00000093470.4, ENSMUST00000095794.4
    4. NM_001421606.1NP_001408535.1  TATA box-binding protein-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166256
      UniProtKB/TrEMBL
      Q8K073
    5. NM_001421607.1NP_001408536.1  TATA box-binding protein-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166256
    6. NM_001421608.1NP_001408537.1  TATA box-binding protein-like 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC166256
    7. NM_011603.6NP_035733.1  TATA box-binding protein-like 1 isoform 1

      See identical proteins and their annotated locations for NP_035733.1

      Status: VALIDATED

      Source sequence(s)
      AC166256
      Consensus CDS
      CCDS23730.1
      UniProtKB/Swiss-Prot
      P62340
      UniProtKB/TrEMBL
      Q8K073
      Related
      ENSMUSP00000114223.2, ENSMUST00000127698.8
      Conserved Domains (1) summary
      cd04517
      Location:9180
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      22579776..22607882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)