U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Wwox WW domain-containing oxidoreductase [ Mus musculus (house mouse) ]

    Gene ID: 80707, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wwoxprovided by MGI
    Official Full Name
    WW domain-containing oxidoreductaseprovided by MGI
    Primary source
    MGI:MGI:1931237
    See related
    Ensembl:ENSMUSG00000004637 AllianceGenome:MGI:1931237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WOX1; 5330426P09Rik; 9030416C10Rik
    Summary
    Enables enzyme binding activity. Contributes to transcription coactivator activity. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of extrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in mitochondrion and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and skeleton. Used to study autosomal recessive spinocerebellar ataxia 12. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 2.7), adrenal adult (RPKM 2.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wwox in Genome Data Viewer
    Location:
    8 E1; 8 60.99 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (115166377..116079451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (114439635..115352712)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933408N05 gene Neighboring gene vesicle amine transport protein 1 like Neighboring gene STARR-positive B cell enhancer ABC_E3807 Neighboring gene STARR-seq mESC enhancer starr_22773 Neighboring gene predicted gene, 30330 Neighboring gene C-type lectin domain family 3, member a Neighboring gene STARR-seq mESC enhancer starr_22775 Neighboring gene STARR-seq mESC enhancer starr_22776 Neighboring gene predicted gene 16116 Neighboring gene predicted gene, 30554 Neighboring gene predicted gene 16117 Neighboring gene STARR-seq mESC enhancer starr_22777 Neighboring gene predicted gene 16118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:117339207-117339316 Neighboring gene predicted gene, 53457 Neighboring gene STARR-positive B cell enhancer ABC_E6688 Neighboring gene STARR-positive B cell enhancer ABC_E2274 Neighboring gene STARR-seq mESC enhancer starr_22780 Neighboring gene STARR-seq mESC enhancer starr_22781 Neighboring gene predicted gene, 39257 Neighboring gene STARR-seq mESC enhancer starr_22782 Neighboring gene STARR-seq mESC enhancer starr_22783 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:117758115-117758268 Neighboring gene STARR-seq mESC enhancer starr_22784 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:117938195-117938396 Neighboring gene STARR-seq mESC enhancer starr_22785 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:118038529-118038730 Neighboring gene STARR-seq mESC enhancer starr_22786 Neighboring gene predicted gene, 23677 Neighboring gene MAF bZIP transcription factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WW domain-containing oxidoreductase
    Names
    WW-domain oxidoreductase
    NP_001402027.1
    NP_001402028.1
    NP_001402029.1
    NP_001402030.1
    NP_062519.2
    XP_006531573.1
    XP_006531574.1
    XP_006531575.1
    XP_006531576.1
    XP_006531578.1
    XP_011246858.1
    XP_011246859.1
    XP_011246860.1
    XP_036010283.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415098.1NP_001402027.1  WW domain-containing oxidoreductase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110576, AC129777, AC151980
    2. NM_001415099.1NP_001402028.1  WW domain-containing oxidoreductase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110576, AC129777, AC151980
    3. NM_001415100.1NP_001402029.1  WW domain-containing oxidoreductase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC110576, AC151980
      Related
      ENSMUSP00000125626.2, ENSMUST00000160862.8
    4. NM_001415101.1NP_001402030.1  WW domain-containing oxidoreductase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC110576, AC142145, AC151980
    5. NM_019573.4NP_062519.2  WW domain-containing oxidoreductase isoform 1

      See identical proteins and their annotated locations for NP_062519.2

      Status: VALIDATED

      Source sequence(s)
      AC110576, AC129777, AC151980
      Consensus CDS
      CCDS22691.1
      UniProtKB/Swiss-Prot
      Q8C8J6, Q91WL8, Q920Y2, Q9D2B3, Q9D339, Q9JLF5
      Related
      ENSMUSP00000004756.8, ENSMUST00000004756.14
      Conserved Domains (3) summary
      cd09809
      Location:124407
      human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
      PRK06196
      Location:107404
      PRK06196; oxidoreductase; Provisional
      cd00201
      Location:1947
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      115166377..116079451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531515.5XP_006531578.1  WW domain-containing oxidoreductase isoform X11

      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124209
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_006531510.5XP_006531573.1  WW domain-containing oxidoreductase isoform X1

      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124352
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_006531512.4XP_006531575.1  WW domain-containing oxidoreductase isoform X4

      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124352
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_011248556.3XP_011246858.1  WW domain-containing oxidoreductase isoform X2

      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124352
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_011248557.4XP_011246859.1  WW domain-containing oxidoreductase isoform X6

      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124352
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. XM_006531511.5XP_006531574.1  WW domain-containing oxidoreductase isoform X3

      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124352
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    7. XM_011248558.4XP_011246860.1  WW domain-containing oxidoreductase isoform X7

      UniProtKB/Swiss-Prot
      Q91WL8
      Related
      ENSMUSP00000104736.3, ENSMUST00000109108.9
      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124353
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    8. XM_006531513.4XP_006531576.1  WW domain-containing oxidoreductase isoform X8

      Conserved Domains (3) summary
      cd00201
      Location:6090
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:1847
      WW; WW domain
      cl21454
      Location:124352
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    9. XM_036154390.1XP_036010283.1  WW domain-containing oxidoreductase isoform X10

      Conserved Domains (1) summary
      cl21454
      Location:17251
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins