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    Snx33 sorting nexin 33 [ Mus musculus (house mouse) ]

    Gene ID: 235406, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snx33provided by MGI
    Official Full Name
    sorting nexin 33provided by MGI
    Primary source
    MGI:MGI:2443239
    See related
    Ensembl:ENSMUSG00000032733 AllianceGenome:MGI:2443239
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sh3px3; E130307J07Rik
    Summary
    Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; plasma membrane tubulation; and regulation of protein localization to cell surface. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. Orthologous to human SNX33 (sorting nexin 33). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 10.6), ovary adult (RPKM 9.3) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Snx33 in Genome Data Viewer
    Location:
    9 B; 9 30.48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56824472..56835726, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56917188..56928442, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 1 Neighboring gene predicted gene, 31586 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene STARR-positive B cell enhancer ABC_E1386 Neighboring gene predicted gene, 19936 Neighboring gene IMP3, U3 small nucleolar ribonucleoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cleavage furrow formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macropinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macropinocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane tubulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sorting nexin-33
    Names
    SH3 and PX domain containing 3
    SH3 and PX domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175483.5NP_780692.2  sorting nexin-33

      See identical proteins and their annotated locations for NP_780692.2

      Status: PROVISIONAL

      Source sequence(s)
      AK142274
      Consensus CDS
      CCDS23212.1
      UniProtKB/Swiss-Prot
      Q4VAA7, Q8BPM5, Q8C832
      Related
      ENSMUSP00000060225.6, ENSMUST00000050916.7
      Conserved Domains (3) summary
      cd07669
      Location:365571
      BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
      cd11896
      Location:458
      SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
      cl02563
      Location:230354
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      56824472..56835726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511091.3XP_006511154.1  sorting nexin-33 isoform X1

      See identical proteins and their annotated locations for XP_006511154.1

      UniProtKB/Swiss-Prot
      Q4VAA7, Q8BPM5, Q8C832
      Conserved Domains (3) summary
      cd07669
      Location:365571
      BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
      cd11896
      Location:458
      SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
      cl02563
      Location:230354
      PX_domain; The Phox Homology domain, a phosphoinositide binding module