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    Ap3m2 adaptor-related protein complex 3, mu 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 64933, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ap3m2provided by MGI
    Official Full Name
    adaptor-related protein complex 3, mu 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1929214
    See related
    Ensembl:ENSMUSG00000031539 AllianceGenome:MGI:1929214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP-3B; 5830445E16Rik
    Summary
    Involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in central nervous system; ganglia; and sensory organ. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 20.8), frontal lobe adult (RPKM 18.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ap3m2 in Genome Data Viewer
    Location:
    8 A2; 8 11.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23277370..23297308, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22787354..22807292, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene inhibitor of kappaB kinase beta Neighboring gene predicted gene 15346 Neighboring gene STARR-seq mESC enhancer starr_20910 Neighboring gene plasminogen activator, tissue Neighboring gene RIKEN cDNA 1700041G16 gene Neighboring gene STARR-seq mESC enhancer starr_20911 Neighboring gene STARR-positive B cell enhancer ABC_E188 Neighboring gene STARR-positive B cell enhancer ABC_E8844 Neighboring gene STARR-positive B cell enhancer ABC_E2859 Neighboring gene STARR-positive B cell enhancer ABC_E6627 Neighboring gene STARR-positive B cell enhancer ABC_E2259 Neighboring gene STARR-seq mESC enhancer starr_20912 Neighboring gene predicted gene, 46036 Neighboring gene predicted gene, 24735 Neighboring gene K(lysine) acetyltransferase 6A Neighboring gene mitochondrial ribosomal protein L4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics. Bubier JA, et al. Genetics, 2014 Aug. PMID 24923803, Free PMC Article
    2. Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. Nakatsu F, et al. J Cell Biol, 2004 Oct 25. PMID 15492041, Free PMC Article
    3. The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes. Blumstein J, et al. J Neurosci, 2001 Oct 15. PMID 11588176, Free PMC Article
    4. Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice. Misawa H, et al. Eur J Neurosci, 2008 Jun. PMID 18554297
    5. Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain. Seong E, et al. Mol Biol Cell, 2005 Jan. PMID 15537701, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin-coated vesicle cargo loading, AP-3-mediated NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle recycling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-3 complex subunit mu-2
    Names
    HA1 47 kDa subunit homolog 2
    P47B
    adapter-related protein complex 3 mu-2 subunit
    adapter-related protein complex 3 subunit mu-2
    adaptor-related protein complex 3 subunit mu-2
    clathrin assembly protein assembly protein complex 1 medium chain homolog 2
    clathrin assembly protein assembly protein complex 3 mu-2 medium chain
    clathrin coat assembly protein AP47 homolog 2
    clathrin coat-associated protein AP47 homolog 2
    golgi adaptor AP-1 47 kDa protein homolog 2
    m3B
    mu3B-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122820.1 → NP_001116292.1  AP-3 complex subunit mu-2

      See identical proteins and their annotated locations for NP_001116292.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK081220, BB610934, BY121529
      Consensus CDS
      CCDS22184.1
      UniProtKB/Swiss-Prot
      Q3UYJ3, Q8R2R9, Q923G7
      Related
      ENSMUSP00000128446.2, ENSMUST00000163739.3
      Conserved Domains (2) summary
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
      cl10970
      Location:165 → 418
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    2. NM_029505.3 → NP_083781.2  AP-3 complex subunit mu-2

      See identical proteins and their annotated locations for NP_083781.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK081220, BB610934
      Consensus CDS
      CCDS22184.1
      UniProtKB/Swiss-Prot
      Q3UYJ3, Q8R2R9, Q923G7
      Related
      ENSMUSP00000147967.2, ENSMUST00000210656.2
      Conserved Domains (2) summary
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
      cl10970
      Location:165 → 418
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      23277370..23297308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243706.1 → XP_030099566.1  AP-3 complex subunit mu-2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UYJ3, Q8R2R9, Q923G7
      Conserved Domains (2) summary
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
      cl10970
      Location:165 → 418
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2R9.1 GenPept UniProtKB/Swiss-Prot:Q8R2R9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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