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    Crtam cytotoxic and regulatory T cell molecule [ Mus musculus (house mouse) ]

    Gene ID: 54698, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crtamprovided by MGI
    Official Full Name
    cytotoxic and regulatory T cell moleculeprovided by MGI
    Primary source
    MGI:MGI:1859822
    See related
    Ensembl:ENSMUSG00000032021 AllianceGenome:MGI:1859822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including detection of tumor cell; establishment of T cell polarity; and regulation of T cell activation. Located in immunological synapse. Orthologous to human CRTAM (cytotoxic and regulatory T cell molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 7.1) and testis adult (RPKM 4.5) See more
    Orthologs
    NEW
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    Genomic context

    See Crtam in Genome Data Viewer
    Location:
    9 A5.1; 9 21.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40880987..40915922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40972798..41004628, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene brain specific homeobox Neighboring gene junctional cadherin complex regulator Neighboring gene ubiquitin specific peptidase 10 pseudogene Neighboring gene ubiquitin associated and SH3 domain containing, B Neighboring gene VISTA enhancer mm1337 Neighboring gene STARR-seq mESC enhancer starr_23876 Neighboring gene interferon-induced transmembrane protein 3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC141606, MGC141607

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell recognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in detection of stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in detection of tumor cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of tumor cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in establishment of T cell polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphocyte migration into lymphoid organs IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of CD8-positive, alpha-beta T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    cytotoxic and regulatory T-cell molecule
    Names
    class I-restricted T cell-associated molecule
    class-I MHC-restricted T-cell-associated molecule

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281954.2NP_001268883.1  cytotoxic and regulatory T-cell molecule isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC159820
      Consensus CDS
      CCDS72216.1
      UniProtKB/Swiss-Prot
      A0A087WPL6, M0QWH9, Q149L7, Q3TQA9, Q9CVZ9, Q9Z151
      UniProtKB/TrEMBL
      E9QPS7
      Related
      ENSMUSP00000137837.2, ENSMUST00000180384.3
      Conserved Domains (3) summary
      smart00410
      Location:22112
      IG_like; Immunoglobulin like
      pfam08205
      Location:119205
      C2-set_2; CD80-like C2-set immunoglobulin domain
      cl11960
      Location:22112
      Ig; Immunoglobulin domain
    2. NM_019465.5NP_062338.3  cytotoxic and regulatory T-cell molecule isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC159820
      Consensus CDS
      CCDS40593.2
      UniProtKB/TrEMBL
      E9QPS7
      Related
      ENSMUSP00000139826.2, ENSMUST00000188848.8
      Conserved Domains (3) summary
      smart00410
      Location:22112
      IG_like; Immunoglobulin like
      pfam08205
      Location:119205
      C2-set_2; CD80-like C2-set immunoglobulin domain
      cl11960
      Location:22112
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      40880987..40915922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)