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    Camk1d calcium/calmodulin-dependent protein kinase ID [ Mus musculus (house mouse) ]

    Gene ID: 227541, updated on 27-Nov-2024

    Summary

    Official Symbol
    Camk1dprovided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase IDprovided by MGI
    Primary source
    MGI:MGI:2442190
    See related
    Ensembl:ENSMUSG00000039145 AllianceGenome:MGI:2442190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CKLiK; mCKLiK; CaMKIdelta; A630059D12Rik; E030025C11Rik
    Summary
    Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in positive regulation of neuron projection development and positive regulation of neutrophil chemotaxis. Acts upstream of or within negative regulation of apoptotic process and positive regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system; liver; and retina. Orthologous to human CAMK1D (calcium/calmodulin dependent protein kinase ID). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 7.4), frontal lobe adult (RPKM 6.1) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Camk1d in Genome Data Viewer
    Location:
    2 A1; 2 3.39 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5298268..5719665, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5293457..5714860, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03560 Neighboring gene STARR-seq mESC enhancer starr_03561 Neighboring gene predicted gene, 23118 Neighboring gene predicted gene 13197 Neighboring gene predicted gene, 36906 Neighboring gene STARR-seq mESC enhancer starr_03563 Neighboring gene predicted gene, 36853 Neighboring gene STARR-seq mESC enhancer starr_03567 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5534743-5534896 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5572598-5572785 Neighboring gene STARR-seq mESC enhancer starr_03568 Neighboring gene STARR-seq mESC enhancer starr_03570 Neighboring gene STARR-seq mESC enhancer starr_03571 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5661717-5662018 Neighboring gene STARR-seq mESC enhancer starr_03574 Neighboring gene predicted gene, 29857 Neighboring gene STARR-seq mESC enhancer starr_03576 Neighboring gene cell division cycle 123 Neighboring gene predicted gene, 29984

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of respiratory burst ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of granulocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of granulocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of granulocyte chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1D
    Names
    caM kinase I delta
    caM kinase ID
    caM-KI delta
    caMKI delta
    calcium/calmodulin-dependent protein kinase 1D
    camKI-like protein kinase
    NP_001277303.1
    NP_001277304.1
    NP_001277305.1
    NP_796317.2
    XP_006497532.1
    XP_006497533.1
    XP_006497534.1
    XP_011237275.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290374.1NP_001277303.1  calcium/calmodulin-dependent protein kinase type 1D isoform b

      See identical proteins and their annotated locations for NP_001277303.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK147616, AK147657, BC141414, BF460707
      UniProtKB/TrEMBL
      Q3TDM2
      Conserved Domains (1) summary
      cl21453
      Location:12287
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001290375.1NP_001277304.1  calcium/calmodulin-dependent protein kinase type 1D isoform c

      See identical proteins and their annotated locations for NP_001277304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK147616, AK147657, BC141414, BF460707
      UniProtKB/TrEMBL
      Q3UH04
      Conserved Domains (1) summary
      cd14168
      Location:12312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
    3. NM_001290376.1NP_001277305.1  calcium/calmodulin-dependent protein kinase type 1D isoform d

      See identical proteins and their annotated locations for NP_001277305.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK147616, AY273822, BC141414, BF460707
      Consensus CDS
      CCDS70975.1
      UniProtKB/Swiss-Prot
      Q8BW96
      UniProtKB/TrEMBL
      B1AW58
      Related
      ENSMUSP00000110638.4, ENSMUST00000114987.4
      Conserved Domains (2) summary
      smart00220
      Location:23271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14083
      Location:23270
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
    4. NM_177343.4NP_796317.2  calcium/calmodulin-dependent protein kinase type 1D isoform a

      See identical proteins and their annotated locations for NP_796317.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK147616, BC141414, BF460707
      Consensus CDS
      CCDS15665.1
      UniProtKB/Swiss-Prot
      Q3U450, Q80W64, Q8BW96, Q8BWI7
      UniProtKB/TrEMBL
      B1AW58
      Related
      ENSMUSP00000037028.8, ENSMUST00000044009.14
      Conserved Domains (1) summary
      cd14168
      Location:12312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      5298268..5719665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497471.5XP_006497534.1  calcium/calmodulin-dependent protein kinase type 1D isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:12268
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011238973.4XP_011237275.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

      Conserved Domains (1) summary
      cd14083
      Location:21271
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
    3. XM_006497469.5XP_006497532.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

      Conserved Domains (1) summary
      cd14083
      Location:3250
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
    4. XM_006497470.5XP_006497533.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

      See identical proteins and their annotated locations for XP_006497533.1

      Conserved Domains (1) summary
      cd14168
      Location:12312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta