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    Tbrg1 transforming growth factor beta regulated gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 21376, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbrg1provided by MGI
    Official Full Name
    transforming growth factor beta regulated gene 1provided by MGI
    Primary source
    MGI:MGI:1100877
    See related
    Ensembl:ENSMUSG00000011114 AllianceGenome:MGI:1100877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Niam; Tb-5; mFLJ00213
    Summary
    Predicted to be involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cranium; genitourinary system; jaw; liver; and spleen. Orthologous to human TBRG1 (transforming growth factor beta regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 174.8), testis adult (RPKM 45.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tbrg1 in Genome Data Viewer
    Location:
    9 A4; 9 20.79 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (37560478..37568608, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (37649182..37657312, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sperm autoantigenic protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E1111 Neighboring gene sialic acid acetylesterase Neighboring gene STARR-seq mESC enhancer starr_23813 Neighboring gene pannexin 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein localization to nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    transforming growth factor beta regulator 1
    Names
    nuclear interactor of ARF and Mdm2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025289.3NP_079565.2  transforming growth factor beta regulator 1

      See identical proteins and their annotated locations for NP_079565.2

      Status: VALIDATED

      Source sequence(s)
      AC160125, BC065795, BQ174234
      Consensus CDS
      CCDS52771.1
      UniProtKB/Swiss-Prot
      Q3TLE7, Q3UB74, Q3UCG2, Q3YBR3, Q6P067, Q80XA1, Q8CGC5
      Related
      ENSMUSP00000112600.2, ENSMUST00000117654.3
      Conserved Domains (2) summary
      pfam05964
      Location:184233
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:239314
      FYRC; F/Y rich C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      37560478..37568608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)