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    Panx3 pannexin 3 [ Mus musculus (house mouse) ]

    Gene ID: 208098, updated on 9-Dec-2024

    Summary

    Official Symbol
    Panx3provided by MGI
    Official Full Name
    pannexin 3provided by MGI
    Primary source
    MGI:MGI:1918881
    See related
    Ensembl:ENSMUSG00000011118 AllianceGenome:MGI:1918881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3230401P04; 4833413G11Rik
    Summary
    Enables calcium channel activity and gap junction hemi-channel activity. Involved in osteoblast differentiation. Located in endoplasmic reticulum membrane; gap junction; and plasma membrane. Is expressed in several structures, including alimentary system; connective tissue; limb; sensory organ; and skeleton. Orthologous to human PANX3 (pannexin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 14.6) and CNS E14 (RPKM 1.6) See more
    Orthologs
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    Genomic context

    See Panx3 in Genome Data Viewer
    Location:
    9 A4; 9 20.79 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (37571198..37580518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (37659902..37669222, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1111 Neighboring gene sialic acid acetylesterase Neighboring gene STARR-seq mESC enhancer starr_23813 Neighboring gene transforming growth factor beta regulated gene 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene tumor protein, translationally-controlled, pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables gap junction hemi-channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables wide pore channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 production IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172454.2NP_766042.2  pannexin-3

      See identical proteins and their annotated locations for NP_766042.2

      Status: VALIDATED

      Source sequence(s)
      AK028288, AK036933, BB849008
      Consensus CDS
      CCDS22984.1
      UniProtKB/Swiss-Prot
      Q8CB28, Q8CEG0
      UniProtKB/TrEMBL
      Q6IMP0
      Related
      ENSMUSP00000011262.3, ENSMUST00000011262.4
      Conserved Domains (1) summary
      cl03000
      Location:35149
      Innexin; Innexin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      37571198..37580518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)