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    Hspa8 heat shock protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 15481, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hspa8provided by MGI
    Official Full Name
    heat shock protein 8provided by MGI
    Primary source
    MGI:MGI:105384
    See related
    Ensembl:ENSMUSG00000015656 AllianceGenome:MGI:105384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; 2410008N15Rik
    Summary
    Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including clathrin coat disassembly; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within chaperone cofactor-dependent protein refolding; positive regulation of mRNA splicing, via spliceosome; and regulation of cell cycle. Located in several cellular components, including extracellular exosome; late endosome; and perinuclear region of cytoplasm. Is active in several cellular components, including glycinergic synapse; photoreceptor ribbon synapse; and postsynaptic specialization membrane. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 956.1), CNS E11.5 (RPKM 802.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hspa8 in Genome Data Viewer
    Location:
    9 A5.1; 9 21.55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40712572..40716498)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40801276..40805202)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CXADR-like membrane protein Neighboring gene predicted gene, 48293 Neighboring gene STARR-seq mESC enhancer starr_23871 Neighboring gene STARR-seq mESC enhancer starr_23872 Neighboring gene predicted gene 16096 Neighboring gene STARR-positive B cell enhancer ABC_E8284 Neighboring gene small nucleolar RNA, C/D box 14C Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14E Neighboring gene STARR-seq mESC enhancer starr_23873 Neighboring gene brain specific homeobox Neighboring gene junctional cadherin complex regulator Neighboring gene ubiquitin specific peptidase 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102007, MGC106514, MGC118485

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables A1 adenosine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables A1 adenosine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent protein disaggregase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables C3HC4-type RING finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin-uncoating ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin-uncoating ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables prostaglandin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables prostaglandin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chaperone-mediated autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chaperone-mediated autophagy translocation complex disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chaperone-mediated protein folding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chaperone-mediated protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in clathrin coat disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within clathrin coat disassembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in clathrin coat disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in late endosomal microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in maintenance of postsynaptic specialization structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation by host of viral process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation by host of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lysosomal membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transmembrane import into intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse organization EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein complex stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nickel cation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to odorant IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in slow axonal transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Prp19 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glycinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glycinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome lumen TAS
    Traceable Author Statement
    more info
     
    located_in lysosomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in neuron spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in photoreceptor ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heat shock cognate 71 kDa protein
    Names
    heat shock 70 kDa protein 8
    heat shock cognate hsc73
    heat shock protein cognate 70
    NP_001351409.1
    NP_112442.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364480.1NP_001351409.1  heat shock cognate 71 kDa protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158355
      Consensus CDS
      CCDS90540.1
      UniProtKB/TrEMBL
      Q3TEK2, Q3TF16, Q3TH56, Q3TQ13, Q3UBA6, Q504P4
      Related
      ENSMUSP00000113722.2, ENSMUST00000117557.8
      Conserved Domains (1) summary
      cl26953
      Location:1594
      HSP70; Hsp70 protein
    2. NM_031165.5NP_112442.2  heat shock cognate 71 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_112442.2

      Status: VALIDATED

      Source sequence(s)
      AK151775, CD774246
      Consensus CDS
      CCDS23083.1
      UniProtKB/Swiss-Prot
      P08109, P12225, P63017, Q3U6R0, Q3U764, Q3U7D7, Q3U7E2, Q3U9B4, Q3U9G0, Q3UGM0, Q5FWJ6, Q62373, Q62374, Q62375, Q6NZD0
      UniProtKB/TrEMBL
      Q3TF16, Q3TH56, Q3TQ13, Q3UBA6
      Related
      ENSMUSP00000015800.10, ENSMUST00000015800.16
      Conserved Domains (1) summary
      PTZ00009
      Location:1613
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      40712572..40716498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)