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    Plekhh2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [ Mus musculus (house mouse) ]

    Gene ID: 213556, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plekhh2provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 2provided by MGI
    Primary source
    MGI:MGI:2146813
    See related
    Ensembl:ENSMUSG00000040852 AllianceGenome:MGI:2146813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA2028; E030001K05
    Summary
    Enables actin binding activity. Involved in negative regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is expressed in s-shaped body. Orthologous to human PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 12.4), limb E14.5 (RPKM 7.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Plekhh2 in Genome Data Viewer
    Location:
    17 E4; 17 55.02 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84819303..84929571)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84511895..84622143)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene thyroid adenoma associated Neighboring gene VISTA enhancer mm1109 Neighboring gene predicted gene, 24722 Neighboring gene STARR-positive B cell enhancer ABC_E7562 Neighboring gene STARR-positive B cell enhancer ABC_E5638 Neighboring gene STARR-seq mESC enhancer starr_43440 Neighboring gene predicted gene, 41642 Neighboring gene RIKEN cDNA 4930500A05 gene Neighboring gene dynein cytoplasmic 2 light intermediate chain 1 Neighboring gene predicted gene, 26066

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC159286

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family H member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357986.1NP_001344915.1  pleckstrin homology domain-containing family H member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132353, AC139329, BP757711
      Consensus CDS
      CCDS28999.1
      UniProtKB/Swiss-Prot
      B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
      Conserved Domains (7) summary
      smart00139
      Location:9541109
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:11221353
      B41; Band 4.1 homologues
      COG1196
      Location:20252
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:13491447
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:705800
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:11191221
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:803916
      PH-like; Pleckstrin homology-like domain
    2. NM_001357987.1NP_001344916.1  pleckstrin homology domain-containing family H member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132353, AC139329, BP757711
      Conserved Domains (6) summary
      smart00139
      Location:651806
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:8191050
      B41; Band 4.1 homologues
      cd13206
      Location:10461144
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:402497
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cl17171
      Location:500613
      PH-like; Pleckstrin homology-like domain
      cl25732
      Location:20252
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_177606.4NP_808274.2  pleckstrin homology domain-containing family H member 2 isoform 1

      See identical proteins and their annotated locations for NP_808274.2

      Status: VALIDATED

      Source sequence(s)
      AC132353, AC139329
      Consensus CDS
      CCDS28999.1
      UniProtKB/Swiss-Prot
      B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
      Related
      ENSMUSP00000039628.6, ENSMUST00000047206.7
      Conserved Domains (7) summary
      smart00139
      Location:9541109
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:11221353
      B41; Band 4.1 homologues
      COG1196
      Location:20252
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:13491447
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:705800
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:11191221
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:803916
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      84819303..84929571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160458.1XP_036016351.1  pleckstrin homology domain-containing family H member 2 isoform X1

      Conserved Domains (7) summary
      smart00139
      Location:10031158
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:11711402
      B41; Band 4.1 homologues
      COG1196
      Location:83301
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:13981496
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:754849
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:11681270
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:852965
      PH-like; Pleckstrin homology-like domain
    2. XM_036160460.1XP_036016353.1  pleckstrin homology domain-containing family H member 2 isoform X4

      Conserved Domains (7) summary
      smart00139
      Location:8891044
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10571288
      B41; Band 4.1 homologues
      COG1196
      Location:3187
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:12841382
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:640735
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:10541156
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:738851
      PH-like; Pleckstrin homology-like domain
    3. XM_030249636.2XP_030105496.1  pleckstrin homology domain-containing family H member 2 isoform X8

      Conserved Domains (6) summary
      smart00139
      Location:395550
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:563794
      B41; Band 4.1 homologues
      cd13206
      Location:790888
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:146241
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:560662
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:244357
      PH-like; Pleckstrin homology-like domain
    4. XM_036160462.1XP_036016355.1  pleckstrin homology domain-containing family H member 2 isoform X7

      Conserved Domains (6) summary
      smart00139
      Location:407562
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:575806
      B41; Band 4.1 homologues
      cd13206
      Location:802900
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:158253
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:572674
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:256369
      PH-like; Pleckstrin homology-like domain
    5. XM_036160461.1XP_036016354.1  pleckstrin homology domain-containing family H member 2 isoform X5

      Conserved Domains (6) summary
      smart00139
      Location:742897
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9101141
      B41; Band 4.1 homologues
      cd13206
      Location:11371235
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:493588
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:9071009
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:591704
      PH-like; Pleckstrin homology-like domain
    6. XM_036160459.1XP_036016352.1  pleckstrin homology domain-containing family H member 2 isoform X1

      Conserved Domains (7) summary
      smart00139
      Location:10031158
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:11711402
      B41; Band 4.1 homologues
      COG1196
      Location:83301
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:13981496
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:754849
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:11681270
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:852965
      PH-like; Pleckstrin homology-like domain
    7. XM_006523993.5XP_006524056.1  pleckstrin homology domain-containing family H member 2 isoform X2

      See identical proteins and their annotated locations for XP_006524056.1

      UniProtKB/Swiss-Prot
      B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
      Conserved Domains (7) summary
      smart00139
      Location:9541109
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:11221353
      B41; Band 4.1 homologues
      COG1196
      Location:20252
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:13491447
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:705800
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:11191221
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:803916
      PH-like; Pleckstrin homology-like domain
    8. XM_017317381.3XP_017172870.1  pleckstrin homology domain-containing family H member 2 isoform X2

      UniProtKB/Swiss-Prot
      B2RQ85, Q059P2, Q69Z29, Q8C115, Q8VDL8
      Conserved Domains (7) summary
      smart00139
      Location:9541109
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:11221353
      B41; Band 4.1 homologues
      COG1196
      Location:20252
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:13491447
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:705800
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:11191221
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:803916
      PH-like; Pleckstrin homology-like domain
    9. XM_011246358.4XP_011244660.1  pleckstrin homology domain-containing family H member 2 isoform X6

      Conserved Domains (7) summary
      smart00139
      Location:700855
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:8681099
      B41; Band 4.1 homologues
      COG1196
      Location:83301
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:10951193
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:451546
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:865967
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:549662
      PH-like; Pleckstrin homology-like domain
    10. XM_006523995.4XP_006524058.1  pleckstrin homology domain-containing family H member 2 isoform X3

      Conserved Domains (7) summary
      smart00139
      Location:9131068
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10811312
      B41; Band 4.1 homologues
      COG1196
      Location:1211
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13206
      Location:13081406
      FERM_C-lobe_PLEKHH1_PLEKHH2; FERM domain C-lobe of Pleckstrin homology domain-containing family H
      cd13282
      Location:664759
      PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
      cd17179
      Location:10781180
      FERM_F1_PLEKHH2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 2 (PLEKHH2)
      cl17171
      Location:762875
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_876465.4 RNA Sequence