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    SLC39A7 solute carrier family 39 member 7 [ Homo sapiens (human) ]

    Gene ID: 7922, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC39A7provided by HGNC
    Official Full Name
    solute carrier family 39 member 7provided by HGNC
    Primary source
    HGNC:HGNC:4927
    See related
    Ensembl:ENSG00000112473 MIM:601416; AllianceGenome:HGNC:4927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KE4; AGM9; HKE4; ZIP7; RING5; H2-KE4; D6S115E; D6S2244E
    Summary
    The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in prostate (RPKM 58.8), placenta (RPKM 52.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC39A7 in Genome Data Viewer
    Location:
    6p21.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33200867..33204437)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33022220..33025790)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33168644..33172214)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33131677-33132178 Neighboring gene collagen type XI alpha 2 chain Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33165434-33165634 Neighboring gene retinoid X receptor beta Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:33168171-33168672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33168673-33169174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33169175-33169676 Neighboring gene RNY4 pseudogene 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33172262-33173144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33173145-33174025 Neighboring gene hydroxysteroid 17-beta dehydrogenase 8 Neighboring gene microRNA 219a-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ferroptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skin epidermis development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    zinc transporter SLC39A7
    Names
    HLA class II region expressed gene KE4
    Ke4 gene, mouse, human homolog of
    histidine-rich membrane protein Ke4
    really interesting new gene 5 protein
    solute carrier family 39 (zinc transporter), member 7
    zinc transporter 7
    zrt-, Irt-like protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077516.2NP_001070984.1  zinc transporter SLC39A7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001070984.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      BC000645, DA573310
      Consensus CDS
      CCDS43453.1
      UniProtKB/Swiss-Prot
      B0UXF6, Q5STP8, Q92504, Q9UIQ0
      UniProtKB/TrEMBL
      A0A024RCX7, A0A1U9X8J5, A0A1U9X8K3, A0A1U9X8L9
      Related
      ENSP00000363807.3, ENST00000374675.7
      Conserved Domains (1) summary
      pfam02535
      Location:132446
      Zip; ZIP Zinc transporter
    2. NM_001288777.2NP_001275706.1  zinc transporter SLC39A7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which contains a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK303158, BC000645
      UniProtKB/Swiss-Prot
      Q92504
      UniProtKB/TrEMBL
      B4DZZ8
      Conserved Domains (1) summary
      pfam02535
      Location:16321
      Zip; ZIP Zinc transporter
    3. NM_006979.3NP_008910.2  zinc transporter SLC39A7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_008910.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC000645, DA573310, DR158641
      Consensus CDS
      CCDS43453.1
      UniProtKB/Swiss-Prot
      B0UXF6, Q5STP8, Q92504, Q9UIQ0
      UniProtKB/TrEMBL
      A0A024RCX7, A0A1U9X8J5, A0A1U9X8K3, A0A1U9X8L9
      Related
      ENSP00000363809.3, ENST00000374677.8
      Conserved Domains (1) summary
      pfam02535
      Location:132446
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      33200867..33204437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      4612372..4615942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      4444366..4447936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      4620340..4623910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      4636820..4640390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      4395271..4398841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      33022220..33025790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)