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    Wnt4 Wnt family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84426, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wnt4provided by RGD
    Official Full Name
    Wnt family member 4provided by RGD
    Primary source
    RGD:621348
    See related
    EnsemblRapid:ENSRNOG00000013166 AllianceGenome:RGD:621348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine activity; frizzled binding activity; and transcription corepressor activity. Involved in cellular response to estradiol stimulus; response to benzoic acid; and response to retinoic acid. Predicted to be located in cell surface; cytoplasm; and extracellular matrix. Predicted to be active in extracellular space. Used to study acute kidney failure. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 107.5), Lung (RPKM 48.1) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wnt4 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (154797245..154818565)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149513573..149535415)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155649238..155668065)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 40 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102552931 Neighboring gene cell division cycle 42 Neighboring gene chymotrypsin like elastase 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC112773

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Sertoli cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within Sertoli cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic epithelial tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic epithelial tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female sex determination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female sex determination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immature T cell proliferation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mammary gland epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesenchymal to epithelial transition IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesenchymal to epithelial transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesonephric tubule development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesonephros development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metanephric nephron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metanephric nephron morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metanephric nephron morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metanephric tubule formation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metanephric tubule formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of androgen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of androgen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of testicular blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of testicular blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of testosterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of testosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nephron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in non-canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within oocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in paramesonephric duct development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within paramesonephric duct development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in paramesonephric duct development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pericyte cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pericyte cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of aldosterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of aldosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collagen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cortisol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cortisol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dermatome development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dermatome development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within renal vesicle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal vesicle induction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within renal vesicle induction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to benzoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to retinoic acid HEP PubMed 
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within sex differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somatotropin secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somatotropin secreting cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tertiary branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tertiary branching involved in mammary gland duct morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thyroid-stimulating hormone-secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein Wnt-4
    Names
    wingless-related MMTV integration site 4
    wingless-type MMTV integration site family, member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053402.2NP_445854.1  protein Wnt-4 precursor

      See identical proteins and their annotated locations for NP_445854.1

      Status: PROVISIONAL

      Source sequence(s)
      AF188608
      UniProtKB/Swiss-Prot
      Q9QXQ5
      UniProtKB/TrEMBL
      A6ITD2, F7ELZ2, Q4G052
      Related
      ENSRNOP00000018064.3, ENSRNOT00000018064.7
      Conserved Domains (1) summary
      pfam00110
      Location:49351
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      154797245..154818565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110876.2XP_038966804.1  protein Wnt-4 isoform X1

      UniProtKB/TrEMBL
      A6ITD2, F7ELZ2, Q4G052
      Conserved Domains (1) summary
      cd19336
      Location:43337
      Wnt_Wnt4; Wnt domain found in protein Wnt-4 and similar proteins