U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293455, updated on 9-Dec-2024

    Summary

    Symbol
    Gga2provided by RGD
    Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by RGD
    Primary source
    RGD:1304800
    See related
    EnsemblRapid:ENSRNOG00000018599 AllianceGenome:RGD:1304800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and protein localization to cell surface. Predicted to be located in Golgi apparatus and clathrin-coated vesicle. Predicted to be active in trans-Golgi network. Orthologous to human GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 433.6), Kidney (RPKM 235.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gga2 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (185983302..186016582, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (176552046..176585332, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (191951578..191984858, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sodium channel epithelial 1 subunit beta Neighboring gene component of oligomeric golgi complex 7 Neighboring gene uncharacterized LOC134483818 Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial Neighboring gene ubiquitin family domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-binding protein GGA2
    Names
    ADP-ribosylation factor-binding protein GGA2-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100519.1NP_001093989.1  ADP-ribosylation factor-binding protein GGA2

      See identical proteins and their annotated locations for NP_001093989.1

      Status: VALIDATED

      Source sequence(s)
      BC098781, CO558907, FM060021
      UniProtKB/TrEMBL
      A0A0G2JYM3, A6I8V4, G3V8F7
      Related
      ENSRNOP00000025309.4, ENSRNOT00000025309.7
      Conserved Domains (4) summary
      smart00809
      Location:482596
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:29166
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cl03906
      Location:229317
      GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
      cl21478
      Location:186242
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      185983302..186016582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)