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    Myrip myosin VIIA and Rab interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360034, updated on 27-Nov-2024

    Summary

    Official Symbol
    Myripprovided by RGD
    Official Full Name
    myosin VIIA and Rab interacting proteinprovided by RGD
    Primary source
    RGD:727731
    See related
    EnsemblRapid:ENSRNOG00000018797 AllianceGenome:RGD:727731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slac2c
    Summary
    Enables protein kinase A binding activity. Involved in positive regulation of insulin secretion. Located in apical plasma membrane; dense core granule; and perinuclear region of cytoplasm. Orthologous to human MYRIP (myosin VIIA and Rab interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 68.6), Lung (RPKM 45.8) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myrip in Genome Data Viewer
    Location:
    8q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128895371..129062420)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (120017749..120184821)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128972307..129139257)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosome recycling factor, pseudogene 2 Neighboring gene uncharacterized LOC102549350 Neighboring gene uncharacterized LOC108351802 Neighboring gene uncharacterized LOC120094297 Neighboring gene transfer RNA proline (anticodon AGG) 29 Neighboring gene eukaryotic translation initiation factor 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
     
    part_of exocyst ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rab effector MyRIP
    Names
    exophilin-8
    myosin-VIIa- and Rab-interacting protein
    slaC2-c
    slp homolog lacking C2 domains c
    synaptotagmin-like protein lacking C2 domains C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182844.3NP_878264.2  rab effector MyRIP

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZTL2
      Related
      ENSRNOP00000025460.6, ENSRNOT00000025460.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      128895371..129062420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081681.2XP_038937609.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Related
      ENSRNOP00000104715.1, ENSRNOT00000164781.1
      Conserved Domains (2) summary
      pfam02318
      Location:8151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    2. XM_039081687.2XP_038937615.1  rab effector MyRIP isoform X4

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178817
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    3. XM_039081688.2XP_038937616.1  rab effector MyRIP isoform X5

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152791
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    4. XM_039081682.2XP_038937610.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    5. XM_039081685.2XP_038937613.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    6. XM_063265675.1XP_063121745.1  rab effector MyRIP isoform X2

      UniProtKB/TrEMBL
      D3ZTL2
    7. XM_039081683.2XP_038937611.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    8. XM_039081684.2XP_038937612.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    9. XM_063265676.1XP_063121746.1  rab effector MyRIP isoform X2

      UniProtKB/TrEMBL
      D3ZTL2
    10. XM_039081686.2XP_038937614.1  rab effector MyRIP isoform X3

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam04698
      Location:140844
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
      cl22851
      Location:1113
      PHD_SF; PHD finger superfamily
    11. XM_008766687.4XP_008764909.1  rab effector MyRIP isoform X6

      See identical proteins and their annotated locations for XP_008764909.1

      Conserved Domains (1) summary
      pfam04698
      Location:1670
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    12. XM_039081689.2XP_038937617.1  rab effector MyRIP isoform X6

      Conserved Domains (1) summary
      pfam04698
      Location:1670
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus