U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Klhdc2 kelch domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299113, updated on 3-Dec-2024

    Summary

    Official Symbol
    Klhdc2provided by RGD
    Official Full Name
    kelch domain containing 2provided by RGD
    Primary source
    RGD:1306504
    See related
    EnsemblRapid:ENSRNOG00000004474 AllianceGenome:RGD:1306504
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nuclear body and nuclear membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human KLHDC2 (kelch domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 423.1), Muscle (RPKM 342.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Klhdc2 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93512981..93552809)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (87777183..87791609)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91595443..91630479)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 1 Neighboring gene DNA polymerase epsilon 2, accessory subunit Neighboring gene transcription factor BTF3-like Neighboring gene nuclear export mediator factor Neighboring gene microRNA mir-3084a-4 Neighboring gene uncharacterized LOC134479213 Neighboring gene ARF GTPase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC124658

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    kelch domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034133.1NP_001029305.1  kelch domain-containing protein 2

      See identical proteins and their annotated locations for NP_001029305.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105756
      UniProtKB/Swiss-Prot
      Q3KRE6
      UniProtKB/TrEMBL
      A0A8I6A1H2
      Related
      ENSRNOP00000103688.1, ENSRNOT00000142020.1
      Conserved Domains (3) summary
      PLN02193
      Location:29296
      PLN02193; nitrile-specifier protein
      sd00038
      Location:218265
      Kelch; KELCH repeat [structural motif]
      pfam13415
      Location:279326
      Kelch_3; Galactose oxidase, central domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93512981..93552809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261703.1XP_063117773.1  kelch domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1H2
      Related
      ENSRNOP00000083418.2, ENSRNOT00000113703.2