Pigx phosphatidylinositol glycan anchor biosynthesis, class X [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pigxprovided by RGD
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Xprovided by RGD
Primary source: RGD:1307289
See related: EnsemblRapid:ENSRNOG00000033623 AllianceGenome:RGD:1307289
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307289
Summary: This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. The protein is translated from a non-AUG translation initiation site. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Liver (RPKM 146.3), Kidney (RPKM 145.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (82192125..82208062)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (68687126..68703067)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (71938388..71954225)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A non-AUG translation initiation site (CUG) is used in rat Pigx
Title: Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol-glycan biosynthesis class X protein

Names: GPI-mannosyltransferase subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100651.1 → NP_001094121.1 phosphatidylinositol-glycan biosynthesis class X protein precursor

Status: REVIEWED

Source sequence(s)

AB177393, DY311520

UniProtKB/Swiss-Prot

Q60GF7

Related

ENSRNOP00000042305.6, ENSRNOT00000043365.7

Conserved Domains (1) summary

pfam08320
Location:48 → 244

PIG-X; PIG-X / PBN1