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    Nemf nuclear export mediator factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100322884, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nemfprovided by RGD
    Official Full Name
    nuclear export mediator factorprovided by RGD
    Primary source
    RGD:2315525
    See related
    EnsemblRapid:ENSRNOG00000056128 AllianceGenome:RGD:2315525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sdccag1
    Summary
    Predicted to enable alpha-aminoacyl-tRNA binding activity and ribosomal large subunit binding activity. Predicted to be involved in CAT tailing; nuclear export; and protein-containing complex assembly. Predicted to be located in cytosol. Predicted to be part of RQC complex. Predicted to be active in cytosolic ribosome. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 149.6), Kidney (RPKM 148.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nemf in Genome Data Viewer
    Location:
    6q24
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93527690..93571863, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (87791650..87835826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91611021..91676394, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 1 Neighboring gene DNA polymerase epsilon 2, accessory subunit Neighboring gene transcription factor BTF3-like Neighboring gene kelch domain containing 2 Neighboring gene microRNA mir-3084a-4 Neighboring gene uncharacterized LOC134479213 Neighboring gene ARF GTPase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-aminoacyl-tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CAT tailing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RQC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosome quality control complex subunit NEMF
    Names
    nuclear export mediator factor NEMF
    serologically defined colon cancer antigen 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170586.3NP_001164057.2  ribosome quality control complex subunit NEMF

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A2E1, A0A8I6ARH7
      Related
      ENSRNOP00000084632.1, ENSRNOT00000098306.2
      Conserved Domains (2) summary
      COG1293
      Location:1642
      YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
      pfam11923
      Location:9641055
      DUF3441; Domain of unknown function (DUF3441)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93527690..93571863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)