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    Galr2 galanin receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29234, updated on 27-Nov-2024

    Summary

    Symbol
    Galr2provided by RGD
    Full Name
    galanin receptor 2provided by RGD
    Primary source
    RGD:2657
    See related
    EnsemblRapid:ENSRNOG00000061733 AllianceGenome:RGD:2657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GAL2-R; GALR-2
    Summary
    Enables galanin receptor activity and neuropeptide binding activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; and phosphatidylinositol metabolic process. Predicted to be located in cilium. Predicted to be active in plasma membrane. Orthologous to human GALR2 (galanin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: In Rnor_6.0 (AR 105), the loci 29234 and 103690156 are placed twice on chromosome 10. This is likely an assembly error and not a true gene duplication. [28 May 2015]
    Expression
    Biased expression in Uterus (RPKM 41.1), Adrenal (RPKM 38.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Galr2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102012086..102016057)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101513689..101517176)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105156793..105159221)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene envoplakin Neighboring gene uncharacterized LOC120095213 Neighboring gene signal recognition particle 68 Neighboring gene exocyst complex component 7 Neighboring gene putative protein CRIPAK Neighboring gene forkhead box J1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galanin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galanin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables galanin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables galanin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in galanin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inositol phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of large conductance calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019172.5NP_062045.1  galanin receptor type 2

      See identical proteins and their annotated locations for NP_062045.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O08726
      UniProtKB/TrEMBL
      A6HKV4
      Related
      ENSRNOP00000073780.1, ENSRNOT00000086288.3
      Conserved Domains (1) summary
      cd15097
      Location:26303
      7tmA_Gal2_Gal3_R; galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102012086..102016057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085711.2XP_038941639.1  galanin receptor type 2 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:1838
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:2181
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_039085710.2XP_038941638.1  galanin receptor type 2 isoform X1

      UniProtKB/TrEMBL
      A6HKV5
      Conserved Domains (2) summary
      cd14964
      Location:2545
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:8188
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily