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    Gch1 GTP cyclohydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29244, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gch1provided by RGD
    Official Full Name
    GTP cyclohydrolase 1provided by RGD
    Primary source
    RGD:61992
    See related
    EnsemblRapid:ENSRNOG00000011039 AllianceGenome:RGD:61992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gch; GTPCH; GTPCH-1
    Summary
    Enables several functions, including GTP binding activity; GTP cyclohydrolase I activity; and metal ion binding activity. Involved in several processes, including dihydrobiopterin metabolic process; negative regulation of cellular senescence; and regulation of apoptotic process. Located in mitochondrion and nucleus. Part of intracellular protein-containing complex. Used to study Parkinsonism; cerebral infarction; hypertension; myocardial infarction; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); liver disease (multiple); middle cerebral artery infarction; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 291.2), Spleen (RPKM 179.1) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gch1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (22884006..22917412, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20404267..20437727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (23935011..23968971, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548367 Neighboring gene ribosomal protein L39, pseudogene 11 Neighboring gene sterile alpha motif domain containing 4A Neighboring gene uncharacterized LOC102548428 Neighboring gene U6 spliceosomal RNA Neighboring gene WD repeat and HMG-box DNA binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP cyclohydrolase I activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP cyclohydrolase I activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables GTP cyclohydrolase I activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP cyclohydrolase I activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in dihydrobiopterin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling posture ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pteridine-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of lung blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tetrahydrobiopterin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of intracellular protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    GTP cyclohydrolase 1
    Names
    GTP cyclohydrase I
    GTP cyclohydrolase I
    GTP-CH-I
    NP_077332.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024356.1NP_077332.1  GTP cyclohydrolase 1 precursor

      See identical proteins and their annotated locations for NP_077332.1

      Status: PROVISIONAL

      Source sequence(s)
      M58364
      UniProtKB/Swiss-Prot
      P22288
      UniProtKB/TrEMBL
      A0A8I5ZYD9, A6KE40
      Related
      ENSRNOP00000014821.5, ENSRNOT00000014821.9
      Conserved Domains (1) summary
      cd00642
      Location:57241
      GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      22884006..22917412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)