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    Dlx5 distal-less homeobox 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25431, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dlx5provided by RGD
    Official Full Name
    distal-less homeobox 5provided by RGD
    Primary source
    RGD:2506
    See related
    EnsemblRapid:ENSRNOG00000010905 AllianceGenome:RGD:2506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RDLX
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to zinc ion starvation and positive regulation of osteoblast differentiation. Predicted to be located in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 9.6), Brain (RPKM 5.3) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dlx5 in Genome Data Viewer
    Location:
    4q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (35965579..35969973, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (34999139..35003504, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (32387741..32392085, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35, pseudogene 9 Neighboring gene uncharacterized LOC100912227 Neighboring gene distal-less homeobox 6 Neighboring gene uncharacterized LOC134486725 Neighboring gene succinate dehydrogenase complex assembly factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anatomical structure formation involved in morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to zinc ion starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within ear development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endochondral ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endochondral ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endochondral ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in face morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within head development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interneuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within interneuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in olfactory bulb interneuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within olfactory bulb interneuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in olfactory pit development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within olfactory pit development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    homeobox protein DLX-5
    Names
    DLX-3
    homeobox protein DLX-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012943.1NP_037075.1  homeobox protein DLX-5

      See identical proteins and their annotated locations for NP_037075.1

      Status: PROVISIONAL

      Source sequence(s)
      L24443
      UniProtKB/TrEMBL
      A0A0G2JSK6, A6IDV1
      Related
      ENSRNOP00000014946.2, ENSRNOT00000014946.5
      Conserved Domains (2) summary
      pfam00046
      Location:140194
      Homeobox; Homeobox domain
      pfam12413
      Location:32118
      DLL_N; Homeobox protein distal-less-like N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      35965579..35969973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592486.3XP_017447975.1  homeobox protein DLX-5 isoform X1