U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Epb41l1 erythrocyte membrane protein band 4.1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59317, updated on 3-Dec-2024

    Summary

    Symbol
    Epb41l1provided by RGD
    Full Name
    erythrocyte membrane protein band 4.1-like 1provided by RGD
    Primary source
    RGD:71087
    See related
    EnsemblRapid:ENSRNOG00000057817 AllianceGenome:RGD:71087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    4.1N; Epb4.1l1
    Summary
    Enables signaling receptor binding activity. Predicted to be involved in actomyosin structure organization and regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane. Located in synaptic membrane. Part of protein-containing complex. Is active in parallel fiber to Purkinje cell synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 11. Orthologous to human EPB41L1 (erythrocyte membrane protein band 4.1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 375.4), Adrenal (RPKM 169.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Epb41l1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165389295..165512821)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144929195..145052723)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152492725..152622047)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene ferritin light chain 1 pseudogene Neighboring gene uncharacterized LOC120101765 Neighboring gene AAR2 splicing factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    band 4.1-like protein 1
    Names
    band 4.1-like protein 1-like
    erythrocyte protein band 4.1-like 1
    neuronal protein 4.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021681.3NP_067713.2  band 4.1-like protein 1 isoform L

      See identical proteins and their annotated locations for NP_067713.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (L).
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K0F3, D3ZMI4
      Related
      ENSRNOP00000071420.1, ENSRNOT00000089719.3
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:14121537
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    2. NM_172090.4NP_742087.1  band 4.1-like protein 1 isoform S

      See identical proteins and their annotated locations for NP_742087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform S, which is shorter than isoform L.
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9WTP0, Q9WTP1
      UniProtKB/TrEMBL
      A6KIB0, D4A9L5
      Related
      ENSRNOP00000071845.4, ENSRNOT00000080543.4
      Conserved Domains (7) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:183288
      FERM_M; FERM central domain
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:741866
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385425
      FA; FERM adjacent (FA)
      pfam09379
      Location:101164
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      165389295..165512821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284435.1XP_063140505.1  band 4.1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0F3, D3ZMI4
    2. XM_017592007.3XP_017447496.1  band 4.1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0F3, D3ZMI4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:14121537
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    3. XM_017592006.3XP_017447495.1  band 4.1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0F3, D3ZMI4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:14121537
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    4. XM_017592010.3XP_017447499.1  band 4.1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0F3, D3ZMI4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:14121537
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    5. XM_063284445.1XP_063140515.1  band 4.1-like protein 1 isoform X14

      UniProtKB/TrEMBL
      D4A9L5
    6. XM_017592005.3XP_017447494.1  band 4.1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0F3, D3ZMI4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:14121537
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    7. XM_063284436.1XP_063140506.1  band 4.1-like protein 1 isoform X8

      UniProtKB/Swiss-Prot
      Q9WTP0, Q9WTP1
      UniProtKB/TrEMBL
      A6KIB0, D4A9L5
      Related
      ENSRNOP00000072128.4, ENSRNOT00000087289.4
    8. XM_063284442.1XP_063140512.1  band 4.1-like protein 1 isoform X12

      UniProtKB/TrEMBL
      D4A9L5
    9. XM_063284440.1XP_063140510.1  band 4.1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2K0B2, A6KIB1, D4A9L5
      Related
      ENSRNOP00000071375.2, ENSRNOT00000085938.4
    10. XM_063284444.1XP_063140514.1  band 4.1-like protein 1 isoform X14

      UniProtKB/TrEMBL
      D4A9L5
    11. XM_063284446.1XP_063140516.1  band 4.1-like protein 1 isoform X15

      UniProtKB/TrEMBL
      D4A9L5
    12. XM_008762381.4XP_008760603.1  band 4.1-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_008760603.1

      UniProtKB/TrEMBL
      A0A0G2K0F3, D3ZMI4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:14121537
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    13. XM_063284438.1XP_063140508.1  band 4.1-like protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2K0B2, A6KIB1, D4A9L5
    14. XM_063284443.1XP_063140513.1  band 4.1-like protein 1 isoform X14

      UniProtKB/TrEMBL
      D4A9L5
    15. XM_063284437.1XP_063140507.1  band 4.1-like protein 1 isoform X9

      UniProtKB/TrEMBL
      D4A9L5
    16. XM_063284441.1XP_063140511.1  band 4.1-like protein 1 isoform X11

      UniProtKB/TrEMBL
      D4A9L5
      Related
      ENSRNOP00000074285.4, ENSRNOT00000087907.4
    17. XM_063284447.1XP_063140517.1  band 4.1-like protein 1 isoform X15

      UniProtKB/TrEMBL
      D4A9L5
    18. XM_039105759.1XP_038961687.1  band 4.1-like protein 1 isoform X6

      UniProtKB/TrEMBL
      D3ZMI4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:14281481
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    19. XM_017592011.1XP_017447500.1  band 4.1-like protein 1 isoform X5

      UniProtKB/TrEMBL
      D3ZMI4
    20. XM_017592012.1XP_017447501.1  band 4.1-like protein 1 isoform X7

      UniProtKB/TrEMBL
      D4A9L5
    21. XM_039105762.1XP_038961690.1  band 4.1-like protein 1 isoform X13

      UniProtKB/TrEMBL
      D4A9L5, D4ACZ4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:493524
      SAB; SAB domain
      pfam05902
      Location:606730
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)
    22. XM_017592004.1XP_017447493.1  band 4.1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      D3ZMI4
    23. XM_063284448.1XP_063140518.1  band 4.1-like protein 1 isoform X16

    24. XM_017592003.1XP_017447492.1  band 4.1-like protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZMI4
    25. XM_039105757.1XP_038961685.1  band 4.1-like protein 1 isoform X4

      UniProtKB/TrEMBL
      D3ZMI4
      Conserved Domains (5) summary
      smart00295
      Location:98288
      B41; Band 4.1 homologues
      cd13184
      Location:283376
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:474504
      SAB; SAB domain
      pfam05902
      Location:13941518
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:385428
      FA; FERM adjacent (FA)