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    Vwa5b2 von Willebrand factor A domain containing 5B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303812, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Vwa5b2provided by RGD
    Official Full Name
    von Willebrand factor A domain containing 5B2provided by RGD
    Primary source
    RGD:1564491
    See related
    EnsemblRapid:ENSRNOG00000001707 AllianceGenome:RGD:1564491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564491
    Summary
    Orthologous to human VWA5B2 (von Willebrand factor A domain containing 5B2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 50.2), Thymus (RPKM 19.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vwa5b2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93810456..93827609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80306067..80323220, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83991793..84008946, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene ALG3, alpha-1,3- mannosyltransferase Neighboring gene microRNA 1224 Neighboring gene uncharacterized LOC102551647 Neighboring gene ATP binding cassette subfamily F member 3 Neighboring gene uncharacterized LOC102551795 Neighboring gene adaptor related protein complex 2 subunit mu 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 5B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134535.1 → NP_001128007.1  von Willebrand factor A domain-containing protein 5B2 isoform 1

      See identical proteins and their annotated locations for NP_001128007.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A6JSA6, D4A7U5
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 556
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      pfam13768
      Location:353 → 501
      VWA_3; von Willebrand factor type A domain

    2. NM_001433292.1 → NP_001420221.1  von Willebrand factor A domain-containing protein 5B2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      D4A7U5

    3. NM_001433293.1 → NP_001420222.1  von Willebrand factor A domain-containing protein 5B2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      93810456..93827609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597972.3 → XP_017453461.1  von Willebrand factor A domain-containing protein 5B2 isoform X3

      UniProtKB/TrEMBL
      D4A7U5
      Conserved Domains (2) summary
      pfam13768
      Location:354 → 501
      VWA_3; von Willebrand factor type A domain
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain

    2. XM_017597969.3 → XP_017453458.1  von Willebrand factor A domain-containing protein 5B2 isoform X1

      UniProtKB/TrEMBL
      D4A7U5
      Conserved Domains (2) summary
      pfam13768
      Location:358 → 505
      VWA_3; von Willebrand factor type A domain
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain

    3. XM_063270480.1 → XP_063126550.1  von Willebrand factor A domain-containing protein 5B2 isoform X7

    4. XM_063270478.1 → XP_063126548.1  von Willebrand factor A domain-containing protein 5B2 isoform X1

      UniProtKB/TrEMBL
      D4A7U5

    5. XM_063270477.1 → XP_063126547.1  von Willebrand factor A domain-containing protein 5B2 isoform X1

      UniProtKB/TrEMBL
      D4A7U5

    6. XM_039088280.2 → XP_038944208.1  von Willebrand factor A domain-containing protein 5B2 isoform X3

      UniProtKB/TrEMBL
      D4A7U5
      Conserved Domains (2) summary
      pfam13768
      Location:354 → 501
      VWA_3; von Willebrand factor type A domain
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain

    7. XM_039088279.2 → XP_038944207.1  von Willebrand factor A domain-containing protein 5B2 isoform X2

      UniProtKB/TrEMBL
      D4A7U5
      Conserved Domains (2) summary
      pfam13768
      Location:358 → 505
      VWA_3; von Willebrand factor type A domain
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain

    8. XM_063270479.1 → XP_063126549.1  von Willebrand factor A domain-containing protein 5B2 isoform X4

      Related
      ENSRNOP00000035500.7, ENSRNOT00000037612.7

    9. XM_017597974.3 → XP_017453463.1  von Willebrand factor A domain-containing protein 5B2 isoform X5

      UniProtKB/TrEMBL
      D4A7U5
      Conserved Domains (1) summary
      pfam13768
      Location:134 → 282
      VWA_3; von Willebrand factor type A domain

    10. XM_006248571.3 → XP_006248633.1  von Willebrand factor A domain-containing protein 5B2 isoform X5

      UniProtKB/TrEMBL
      D4A7U5
      Conserved Domains (1) summary
      pfam13768
      Location:134 → 282
      VWA_3; von Willebrand factor type A domain

    11. XM_039088283.2 → XP_038944211.1  von Willebrand factor A domain-containing protein 5B2 isoform X6

      Conserved Domains (2) summary
      pfam13768
      Location:358 → 505
      VWA_3; von Willebrand factor type A domain
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain

    12. XM_063270481.1 → XP_063126551.1  von Willebrand factor A domain-containing protein 5B2 isoform X8

    13. XM_039088284.2 → XP_038944212.1  von Willebrand factor A domain-containing protein 5B2 isoform X9

      Conserved Domains (2) summary
      pfam13768
      Location:358 → 505
      VWA_3; von Willebrand factor type A domain
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain

    RNA

    1. XR_005491021.2 RNA Sequence

    2. XR_010055951.1 RNA Sequence

    3. XR_010055950.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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