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    Tmem131l transmembrane 131 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679811, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem131lprovided by RGD
    Official Full Name
    transmembrane 131 likeprovided by RGD
    Primary source
    RGD:1583677
    See related
    EnsemblRapid:ENSRNOG00000009837 AllianceGenome:RGD:1583677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305449
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human TMEM131L (transmembrane 131 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 231.7), Spleen (RPKM 217.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tmem131l in Genome Data Viewer
    Location:
    2q34
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (171555673..171689774, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169257659..169391773, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (182897332..183031273, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 2 Neighboring gene uncharacterized LOC134485932 Neighboring gene uncharacterized LOC134485933 Neighboring gene peflin pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    transmembrane protein 131-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399524.1NP_001386453.1  transmembrane protein 131-like isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZRG1
      Related
      ENSRNOP00000013260.6, ENSRNOT00000013260.9
      Conserved Domains (1) summary
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    2. NM_001399525.1NP_001386454.1  transmembrane protein 131-like isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      171555673..171689774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282520.1XP_063138590.1  transmembrane protein 131-like isoform X5

    2. XM_006232547.4XP_006232609.1  transmembrane protein 131-like isoform X1

      Conserved Domains (1) summary
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    3. XM_008761116.4XP_008759338.1  transmembrane protein 131-like isoform X4

      UniProtKB/TrEMBL
      A0A8I6AV47
      Related
      ENSRNOP00000097919.1, ENSRNOT00000115508.2
      Conserved Domains (1) summary
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    4. XM_039103734.2XP_038959662.1  transmembrane protein 131-like isoform X2

      Conserved Domains (1) summary
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    5. XM_063282521.1XP_063138591.1  transmembrane protein 131-like isoform X7

    6. XM_006232549.5XP_006232611.1  transmembrane protein 131-like isoform X3

      Conserved Domains (1) summary
      cl13764
      Location:55138
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    7. XM_006232550.4XP_006232612.1  transmembrane protein 131-like isoform X6

      Conserved Domains (1) summary
      cl13764
      Location:20103
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    RNA

    1. XR_005501038.2 RNA Sequence