Rimbp2 RIMS binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rimbp2provided by RGD
Official Full Name: RIMS binding protein 2provided by RGD
Primary source: RGD:708533
See related: EnsemblRapid:ENSRNOG00000022893 AllianceGenome:RGD:708533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rbp2; RIM-BP2
Summary: Predicted to enable voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in neuromuscular synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of presynaptic membrane potential. Predicted to be located in plasma membrane. Predicted to be active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 95.4), Brain (RPKM 54.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q13

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (33383646..33582259)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (27747615..27946256)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (31393229..31605567)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIM1a and RIM-BP2 are plausible organizers of active zones, and the formation of RIM and RIM-BP condensates may cluster voltage gated calcium channels into nano- or microdomains and position the clustered Ca(2+) channels with Ca(2+) sensors on docked vesicles for efficient and precise synaptic transmissions.
Title: RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation.
Rimbp2 is identified in rats.
Title: Structure and evolution of RIM-BP genes: identification of a novel family member.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF386435 (e-PCR)
- UniSTS:243731

BE105245 (e-PCR)
- UniSTS:245788

BE097070 (e-PCR)
- UniSTS:244597

BF390440 (e-PCR)
- UniSTS:249467

BG381331 (e-PCR)
- UniSTS:260771

BF399187 (e-PCR)
- UniSTS:247550

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of presynaptic active zone	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in maintenance of presynaptic active zone structure	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RIMS-binding protein 2

Names: RIM binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100488.4 → NP_001093958.1 RIMS-binding protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I5ZR68, A0A8I6A6H1

Related

ENSRNOP00000080836.1, ENSRNOT00000100361.2

Conserved Domains (6) summary

cd12012
Location:876 → 937

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:980 → 1040

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12014
Location:192 → 252

SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:508 → 594

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:414 → 478

fn3; Fibronectin type III domain

pfam15152
Location:642 → 683

Kisspeptin; Kisspeptin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

33383646..33582259

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271095.1 → XP_063127165.1 RIMS-binding protein 2 isoform X2

Related

ENSRNOP00000073070.3, ENSRNOT00000086078.3
XM_063271096.1 → XP_063127166.1 RIMS-binding protein 2 isoform X3
XM_039089127.2 → XP_038945055.1 RIMS-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K4J8

Related

ENSRNOP00000059643.3, ENSRNOT00000067867.6

Conserved Domains (7) summary

cd12012
Location:1106 → 1167

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1210 → 1270

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12014
Location:185 → 245

SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

PHA03321
Location:582 → 728

PHA03321; tegument protein VP11/12; Provisional

cd00063
Location:501 → 587

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:407 → 474

fn3; Fibronectin type III domain

pfam15905
Location:4 → 88

HMMR_N; Hyaluronan mediated motility receptor N-terminal
XM_063271099.1 → XP_063127169.1 RIMS-binding protein 2 isoform X5

UniProtKB/TrEMBL

A6J0T2
XM_063271100.1 → XP_063127170.1 RIMS-binding protein 2 isoform X6
XM_063271097.1 → XP_063127167.1 RIMS-binding protein 2 isoform X4
XM_039089126.2 → XP_038945054.1 RIMS-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K4J8

Conserved Domains (7) summary

cd12012
Location:1106 → 1167

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1210 → 1270

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12014
Location:185 → 245

SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

PHA03321
Location:582 → 728

PHA03321; tegument protein VP11/12; Provisional

cd00063
Location:501 → 587

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:407 → 474

fn3; Fibronectin type III domain

pfam15905
Location:4 → 88

HMMR_N; Hyaluronan mediated motility receptor N-terminal
XM_063271102.1 → XP_063127172.1 RIMS-binding protein 2 isoform X7

Related

ENSRNOP00000087009.1, ENSRNOT00000115151.2
XM_039089128.2 → XP_038945056.1 RIMS-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K4J8

Related

ENSRNOP00000030915.5, ENSRNOT00000033379.6

Conserved Domains (7) summary

cd12012
Location:1106 → 1167

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1210 → 1270

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12014
Location:185 → 245

SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

PHA03321
Location:582 → 728

PHA03321; tegument protein VP11/12; Provisional

cd00063
Location:501 → 587

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:407 → 474

fn3; Fibronectin type III domain

pfam15905
Location:4 → 88

HMMR_N; Hyaluronan mediated motility receptor N-terminal
XM_039089129.2 → XP_038945057.1 RIMS-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K4J8

Conserved Domains (7) summary

cd12012
Location:1106 → 1167

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1210 → 1270

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12014
Location:185 → 245

SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

PHA03321
Location:582 → 728

PHA03321; tegument protein VP11/12; Provisional

cd00063
Location:501 → 587

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:407 → 474

fn3; Fibronectin type III domain

pfam15905
Location:4 → 88

HMMR_N; Hyaluronan mediated motility receptor N-terminal
XM_063271098.1 → XP_063127168.1 RIMS-binding protein 2 isoform X4

Related

ENSRNOP00000111280.1, ENSRNOT00000158624.1
XM_063271094.1 → XP_063127164.1 RIMS-binding protein 2 isoform X1