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    Hcrt hypocretin [ Mus musculus (house mouse) ]

    Gene ID: 15171, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hcrtprovided by MGI
    Official Full Name
    hypocretinprovided by MGI
    Primary source
    MGI:MGI:1202306
    See related
    Ensembl:ENSMUSG00000045471 AllianceGenome:MGI:1202306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PPOX
    Summary
    This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in testis adult (RPKM 1.4), CNS E18 (RPKM 0.7) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Hcrt in Genome Data Viewer
    Location:
    11 D; 11 63.6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100652519..100653757, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100761693..100762931, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RAB5C, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E3022 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E8452 Neighboring gene STARR-positive B cell enhancer ABC_E5278 Neighboring gene STARR-positive B cell enhancer ABC_E8453 Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene STARR-positive B cell enhancer ABC_E8454 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100681071-100681254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100707044-100707332

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC151320, MGC151346

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 1 orexin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 1 orexin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 1 orexin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 2 orexin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 2 orexin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 2 orexin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in eating behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transmission of nerve impulse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to alcohol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sleep IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in temperature homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in neuronal dense core vesicle lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hypocretin neuropeptide precursor
    Names
    hypocretin neuropeptide
    orexin A
    orexin B
    prepro-orexin
    preprohypocretin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010410.2NP_034540.1  hypocretin neuropeptide precursor precursor

      See identical proteins and their annotated locations for NP_034540.1

      Status: REVIEWED

      Source sequence(s)
      AF019566
      Consensus CDS
      CCDS25436.1
      UniProtKB/Swiss-Prot
      O55241
      UniProtKB/TrEMBL
      Q547R2
      Related
      ENSMUSP00000057578.4, ENSMUST00000055083.4
      Conserved Domains (1) summary
      pfam02072
      Location:1129
      Orexin; Prepro-orexin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100652519..100653757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)