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    Phf11a PHD finger protein 11A [ Mus musculus (house mouse) ]

    Gene ID: 219131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phf11aprovided by MGI
    Official Full Name
    PHD finger protein 11Aprovided by MGI
    Primary source
    MGI:MGI:1918441
    See related
    Ensembl:ENSMUSG00000044703 AllianceGenome:MGI:1918441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phf11; Phf11l; 4933417L10Rik
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within regulation of immune response. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in nucleus. Orthologous to human PHF11 (PHD finger protein 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 2.6), mammary gland adult (RPKM 2.4) and 21 other tissues See more
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    Genomic context

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    See Phf11a in Genome Data Viewer
    Location:
    14 C3; 14 31.48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59514362..59534972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59276913..59297564, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36837 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 Neighboring gene PHD finger protein 11 Neighboring gene STARR-positive B cell enhancer mm9_chr14:59916339-59916640 Neighboring gene PHD finger protein 11B Neighboring gene STARR-positive B cell enhancer ABC_E11570 Neighboring gene STARR-seq mESC enhancer starr_36838 Neighboring gene PHD finger protein 11D Neighboring gene STARR-seq mESC enhancer starr_36839

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant. Zhang Y, et al. Mamm Genome, 2014 Dec. PMID 25091723, Free PMC Article
    2. PHF11 promotes DSB resection, ATR signaling, and HR. Gong Y, et al. Genes Dev, 2017 Jan 1. PMID 28115467, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 11A
    Names
    PHD finger protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172603.3 → NP_766191.1  PHD finger protein 11A

      See identical proteins and their annotated locations for NP_766191.1

      Status: VALIDATED

      Source sequence(s)
      BY162942, EU155109
      Consensus CDS
      CCDS27169.1
      UniProtKB/Swiss-Prot
      Q8BVM9
      Related
      ENSMUSP00000053146.5, ENSMUST00000062307.5
      Conserved Domains (1) summary
      cl22851
      Location:28 → 142
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      59514362..59534972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315970.3 → XP_017171459.1  PHD finger protein 11A isoform X2

      Conserved Domains (1) summary
      cl22851
      Location:28 → 142
      PHD_SF; PHD finger superfamily

    2. XM_011245023.4 → XP_011243325.1  PHD finger protein 11A isoform X1

      Conserved Domains (1) summary
      cl22851
      Location:6 → 120
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVM9.1 GenPept UniProtKB/Swiss-Prot:Q8BVM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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