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Lrrk2 leucine-rich repeat kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 66725, updated on 17-Dec-2024

Summary

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Official Symbol: Lrrk2provided by MGI
Official Full Name: leucine-rich repeat kinase 2provided by MGI
Primary source: MGI:MGI:1913975
See related: Ensembl:ENSMUSG00000036273 AllianceGenome:MGI:1913975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm927; cI-46; 4921513O20Rik; 9330188B09Rik; D630001M17Rik
Summary: Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; protein import into nucleus; and protein phosphorylation. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in kidney adult (RPKM 2.7), lung adult (RPKM 2.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

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See Lrrk2 in Genome Data Viewer

Location:: 15 E3; 15 46.07 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (91556994..91700327)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (91672791..91816124)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRK2 G2019S enhances immune response pathways and aggravates asthma in mouse models.
Title: LRRK2 G2019S enhances immune response pathways and aggravates asthma in mouse models.
Loss of mitochondrial Ca[2+] response and CaMKII/ERK activation by LRRK2[R1441G] mutation correlate with impaired depolarization-induced mitophagy.
Title: Loss of mitochondrial Ca(2+) response and CaMKII/ERK activation by LRRK2(R1441G) mutation correlate with impaired depolarization-induced mitophagy.
Biphenotypic Cells and alpha-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice.
Title: Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice.
TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.
Title: TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.
Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity.
Title: Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity.
Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice.
Title: Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice.
The LRRK2-G2019S mutation attenuates repair of brain injury partially by reducing the release of osteopontin-containing monocytic exosome-like vesicles.
Title: The LRRK2-G2019S mutation attenuates repair of brain injury partially by reducing the release of osteopontin-containing monocytic exosome-like vesicles.
Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.
Title: Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.
LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease.
Title: LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease.
LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation.
Title: LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (194)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (28) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Roc3 (e-PCR)
- UniSTS:510487

D15Roc4 (e-PCR)
- UniSTS:510488

Lrrk2 (e-PCR), detects polymorphism
- UniSTS:525625

ECD18401 (e-PCR)
- UniSTS:299412

D15Mit281 (e-PCR), detects polymorphism
- UniSTS:127649

REN25577 (e-PCR)
- UniSTS:350377

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info	PubMed
enables GTP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin destruction complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables peroxidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peroxidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IC Inferred by Curator more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor complex adaptor activity	IC Inferred by Curator more info	PubMed
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IEA Inferred from Electronic Annotation more info
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Golgi organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Wnt signalosome assembly	IC Inferred by Curator more info	PubMed
involved_in Wnt signalosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dopamine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dopamine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to manganese ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to manganese ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in intracellular distribution of mitochondria	IEA Inferred from Electronic Annotation more info
involved_in intracellular distribution of mitochondria	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion localization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular junction development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection arborization	IEA Inferred from Electronic Annotation more info
involved_in neuron projection arborization	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in olfactory bulb development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to endoplasmic reticulum exit site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of CAMKK-AMPK signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of CAMKK-AMPK signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ER to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of branching morphogenesis of a nerve	IEA Inferred from Electronic Annotation more info
involved_in regulation of branching morphogenesis of a nerve	ISO Inferred from Sequence Orthology more info
involved_in regulation of cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical Wnt signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of cell projection organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of kidney size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion	ISO Inferred from Sequence Orthology more info
involved_in regulation of lysosomal lumen pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of lysosomal lumen pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron maturation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in regulation of retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in striatum development	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle recycling	TAS Traceable Author Statement more info	PubMed
involved_in tangential migration from the subventricular zone to the olfactory bulb	IEA Inferred from Electronic Annotation more info
involved_in tangential migration from the subventricular zone to the olfactory bulb	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	ISO Inferred from Sequence Orthology more info
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of Wnt signalosome	ISO Inferred from Sequence Orthology more info
located_in amphisome	IEA Inferred from Electronic Annotation more info
located_in amphisome	ISO Inferred from Sequence Orthology more info
located_in autolysosome	IEA Inferred from Electronic Annotation more info
located_in autolysosome	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola neck	IEA Inferred from Electronic Annotation more info
located_in caveola neck	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in multivesicular body, internal vesicle	IEA Inferred from Electronic Annotation more info
located_in multivesicular body, internal vesicle	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	IC Inferred by Curator more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat serine/threonine-protein kinase 2

NP_080006.3

EC 2.7.11.1

XP_006521340.1

EC 2.7.11.1

XP_036015439.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025730.3 → NP_080006.3 leucine-rich repeat serine/threonine-protein kinase 2

See identical proteins and their annotated locations for NP_080006.3

Status: VALIDATED

Source sequence(s)

AC099704, AC158752, AK014886, AK014938, AK034413, AK050702, AK052591, BF660966

Consensus CDS

CCDS37180.1

UniProtKB/Swiss-Prot

E9QNJ2, Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062

Related

ENSMUSP00000052584.7, ENSMUST00000060642.7

Conserved Domains (6) summary

cd09914
Location:1334 → 1507

RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family

smart00220
Location:1884 → 2128

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG1100
Location:1333 → 1551

Gem1; GTPase SAR1 family domain [General function prediction only]

cd14068
Location:1884 → 2135

STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2

sd00033
Location:1013 → 1036

LRR_RI; leucine-rich repeat [structural motif]

pfam16095
Location:1527 → 1740

COR; C-terminal of Roc, COR, domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

91556994..91700327

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521277.5 → XP_006521340.1 leucine-rich repeat serine/threonine-protein kinase 2 isoform X2

Conserved Domains (5) summary

PRK15370
Location:1014 → 1290

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

cd09914
Location:1334 → 1507

RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family

sd00033
Location:1013 → 1036

LRR_RI; leucine-rich repeat [structural motif]

pfam16095
Location:1527 → 1740

COR; C-terminal of Roc, COR, domain

cl21453
Location:1884 → 2036

PKc_like; Protein Kinases, catalytic domain
XM_036159546.1 → XP_036015439.1 leucine-rich repeat serine/threonine-protein kinase 2 isoform X1

Conserved Domains (5) summary

PRK15370
Location:969 → 1245

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

cd09914
Location:1289 → 1462

RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family

cd14068
Location:1839 → 2090

STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2

sd00033
Location:968 → 991

LRR_RI; leucine-rich repeat [structural motif]

pfam16095
Location:1482 → 1695

COR; C-terminal of Roc, COR, domain