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    Gsdmc4 gasdermin C4 [ Mus musculus (house mouse) ]

    Gene ID: 74548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gsdmc4provided by MGI
    Official Full Name
    gasdermin C4provided by MGI
    Primary source
    MGI:MGI:1921798
    See related
    Ensembl:ENSMUSG00000055748 AllianceGenome:MGI:1921798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GsdmC-2; 9030605I04Rik
    Summary
    Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptotic inflammatory response. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in genitourinary system and gut. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 65.4), large intestine adult (RPKM 35.7) and 2 other tissues See more
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    Genomic context

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    See Gsdmc4 in Genome Data Viewer
    Location:
    15 D1; 15 28.07 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63762989..63784168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63891140..63912319, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C3 Neighboring gene gasdermin C-like 2 Neighboring gene gasdermin C-like, pseudogene Neighboring gene CYFIP related Rac1 interactor B Neighboring gene STARR-seq mESC enhancer starr_38847 Neighboring gene predicted gene, 25628

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Fattinger SA, et al. Proc Natl Acad Sci U S A, 2023 Nov 28. PMID 37988464, Free PMC Article
    2. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798
    3. Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Grassmeyer J, et al. Dev Biol, 2017 Apr 1. PMID 28215940, Free PMC Article
    4. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables wide pore channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyroptotic inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gasdermin-C4
    Names
    gasderminC-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028992.1 → NP_083268.1  gasdermin-C4

      See identical proteins and their annotated locations for NP_083268.1

      Status: VALIDATED

      Source sequence(s)
      AK018537, AK163061, BY460367
      Consensus CDS
      CCDS49617.1
      UniProtKB/Swiss-Prot
      E9QKJ0, Q3TR54, Q9D326
      UniProtKB/TrEMBL
      A0A679B0N4
      Related
      ENSMUSP00000140269.2, ENSMUST00000188108.7
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 233
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      63762989..63784168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521502.4 → XP_006521565.1  gasdermin-C4 isoform X1

      See identical proteins and their annotated locations for XP_006521565.1

      UniProtKB/Swiss-Prot
      E9QKJ0, Q3TR54, Q9D326
      UniProtKB/TrEMBL
      A0A679B0N4
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 233
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    2. XM_011245757.3 → XP_011244059.1  gasdermin-C4 isoform X2

      Conserved Domains (2) summary
      pfam04598
      Location:4 → 233
      Gasdermin; Gasdermin family
      pfam17708
      Location:265 → 432
      Gasdermin_C; Gasdermin PUB domain

    3. XM_011245754.3 → XP_011244056.1  gasdermin-C4 isoform X1

      See identical proteins and their annotated locations for XP_011244056.1

      UniProtKB/Swiss-Prot
      E9QKJ0, Q3TR54, Q9D326
      UniProtKB/TrEMBL
      A0A679B0N4
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 233
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    4. XM_011245755.4 → XP_011244057.1  gasdermin-C4 isoform X1

      See identical proteins and their annotated locations for XP_011244057.1

      UniProtKB/Swiss-Prot
      E9QKJ0, Q3TR54, Q9D326
      UniProtKB/TrEMBL
      A0A679B0N4
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 233
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    5. XM_011245756.3 → XP_011244058.1  gasdermin-C4 isoform X1

      See identical proteins and their annotated locations for XP_011244058.1

      UniProtKB/Swiss-Prot
      E9QKJ0, Q3TR54, Q9D326
      UniProtKB/TrEMBL
      A0A679B0N4
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 233
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TR54.2 GenPept UniProtKB/Swiss-Prot:Q3TR54

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