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    Slc5a12 solute carrier family 5 (sodium/glucose cotransporter), member 12 [ Mus musculus (house mouse) ]

    Gene ID: 241612, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc5a12provided by MGI
    Official Full Name
    solute carrier family 5 (sodium/glucose cotransporter), member 12provided by MGI
    Primary source
    MGI:MGI:2138890
    See related
    Ensembl:ENSMUSG00000041644 AllianceGenome:MGI:2138890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMCT2; D630015G19
    Summary
    Enables lactate transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in apical plasma membrane and nucleoplasm. Is expressed in cortical early proximal tubule and renal proximal tubule. Orthologous to human SLC5A12 (solute carrier family 5 member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 48.3) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc5a12 in Genome Data Viewer
    Location:
    2 E3; 2 56.75 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (110427644..110479690)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (110597299..110649345)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30319 Neighboring gene STARR-seq mESC enhancer starr_05369 Neighboring gene fin bud initiation factor homolog (zebrafish) Neighboring gene STARR-seq mESC enhancer starr_05370 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_05371 Neighboring gene STARR-seq mESC enhancer starr_05372 Neighboring gene predicted gene, 52522 Neighboring gene anoctamin 3 Neighboring gene mucin 15 Neighboring gene STARR-seq mESC enhancer starr_05373 Neighboring gene POTE ankyrin domain family member 1 Neighboring gene RB1-inducible coiled-coil 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lactate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lactate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monocarboxylate:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium-coupled monocarboxylate transporter 2
    Names
    electroneutral sodium monocarboxylate cotransporter
    low-affinity sodium-lactate cotransporter
    sodium solute cotransporter
    solute carrier family 5 member 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003915.2NP_001003915.1  sodium-coupled monocarboxylate transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_001003915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL732495, BX005257
      Consensus CDS
      CCDS16512.1
      UniProtKB/Swiss-Prot
      Q49B93
      Related
      ENSMUSP00000047340.7, ENSMUST00000045972.13
      Conserved Domains (1) summary
      cl00456
      Location:3531
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_001177624.1NP_001171095.1  sodium-coupled monocarboxylate transporter 2 isoform 2

      See identical proteins and their annotated locations for NP_001171095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK165419, AL732495, BX005257
      Consensus CDS
      CCDS50656.1
      UniProtKB/Swiss-Prot
      Q0D2G1, Q49B93, Q6A4K8
      UniProtKB/TrEMBL
      B9EJ03
      Related
      ENSMUSP00000106655.3, ENSMUST00000111026.3
      Conserved Domains (1) summary
      cd11520
      Location:3527
      SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      110427644..110479690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499489.4XP_006499552.1  sodium-coupled monocarboxylate transporter 2 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:1339
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain