Ttll7 tubulin tyrosine ligase-like family, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttll7provided by MGI
Official Full Name: tubulin tyrosine ligase-like family, member 7provided by MGI
Primary source: MGI:MGI:1918142
See related: Ensembl:ENSMUSG00000036745 AllianceGenome:MGI:1918142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mTTLL7; C630030B20; 1110049N09Rik; 4921517B04Rik
Summary: Enables tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in 1-cell stage embryo and 8-cell stage embryo. Orthologous to human TTLL7 (tubulin tyrosine ligase like 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 11.7), cortex adult (RPKM 10.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 72.28 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (146557312..146690156)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (146852184..146984009)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain.
Title: Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain.
Distinct roles of alpha- and beta-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration.
Title: Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration.
TTLL7, the most abundant neuronal glutamylase, adds glutamates preferentially to the beta-tubulin tail; coupled with ensemble and single-molecule biochemistry, the hybrid X-ray and cryo-electron microscopy structure of TTLL7 bound to the microtubule delineates a tripartite microtubule recognition strategy.
Title: Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.
TTLL7 performs both the initiation and elongation of polyglutamylation on beta-tubulin; the mechanism of binding of three substrates glutamate, ATP, and tubulin to the enzyme is a random sequential pathway.
Title: Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway.
TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites
Title: TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-glutamic acid ligase activity, elongating	IEA Inferred from Electronic Annotation more info
enables protein-glutamic acid ligase activity, initiating	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables tubulin-glutamic acid ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tubulin-glutamic acid ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in protein polyglutamylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein polyglutamylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyglutamylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+0 non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin polyglutamylase TTLL7

Names: polyglutamylase; tubulin--tyrosine ligase-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302957.2 → NP_001289886.1 tubulin polyglutamylase TTLL7 isoform Ttll7

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (Ttll7).

Source sequence(s)

AC165225, AM690751, BP758417, CJ110550

Consensus CDS

CCDS51094.2

UniProtKB/Swiss-Prot

A4Q9E9, A4Q9F0, Q8C417, Q9D5V3

UniProtKB/TrEMBL

A0A0G2LB90

Related

ENSMUSP00000043753.8, ENSMUST00000037942.11

Conserved Domains (1) summary

pfam03133
Location:91 → 376

TTL; Tubulin-tyrosine ligase family
NM_001302958.1 → NP_001289887.1 tubulin polyglutamylase TTLL7 isoform Ttll7s

See identical proteins and their annotated locations for NP_001289887.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several 3' exons but includes an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (Ttll7s) has a distinct C-terminus and is shorter than isoform Ttll7.

Source sequence(s)

AK014905, AM690750, CJ110550

UniProtKB/Swiss-Prot

A4Q9F0

Related

ENSMUST00000038090.12

Conserved Domains (1) summary

pfam03133
Location:91 → 376

TTL; Tubulin-tyrosine ligase family
NM_001357217.1 → NP_001344146.1 tubulin polyglutamylase TTLL7 isoform 3

Status: VALIDATED

Source sequence(s)

AC115889, AC165225, BM899995

Consensus CDS

CCDS89701.1

UniProtKB/TrEMBL

E9PWB8, E9Q6C6

Related

ENSMUSP00000101740.2, ENSMUST00000106134.4

Conserved Domains (1) summary

pfam03133
Location:91 → 376

TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

146557312..146690156

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163314.1 → XP_036019207.1 tubulin polyglutamylase TTLL7 isoform X3

UniProtKB/Swiss-Prot

A4Q9E9, A4Q9F0, Q8C417, Q9D5V3

Conserved Domains (1) summary

pfam03133
Location:91 → 376

TTL; Tubulin-tyrosine ligase family
XM_036163315.1 → XP_036019208.1 tubulin polyglutamylase TTLL7 isoform X4

UniProtKB/TrEMBL

E9PWB8

Conserved Domains (1) summary

pfam03133
Location:91 → 376

TTL; Tubulin-tyrosine ligase family
XM_036163312.1 → XP_036019205.1 tubulin polyglutamylase TTLL7 isoform X1

UniProtKB/Swiss-Prot

A4Q9E9, A4Q9F0, Q8C417, Q9D5V3

Conserved Domains (1) summary

pfam03133
Location:91 → 376

TTL; Tubulin-tyrosine ligase family
XM_036163313.1 → XP_036019206.1 tubulin polyglutamylase TTLL7 isoform X2

UniProtKB/TrEMBL

E9PWB8

Conserved Domains (1) summary

pfam03133
Location:91 → 376

TTL; Tubulin-tyrosine ligase family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_027594.1: Suppressed sequence

Description

NM_027594.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.