Gbx1 gastrulation brain homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gbx1provided by MGI
Official Full Name: gastrulation brain homeobox 1provided by MGI
Primary source: MGI:MGI:95667
See related: Ensembl:ENSMUSG00000067724 AllianceGenome:MGI:95667
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gbx-1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within adult walking behavior; neuron differentiation; and proprioception. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; eye; and male reproductive gland or organ. Orthologous to human GBX1 (gastrulation brain homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E14 (RPKM 1.1), whole brain E14.5 (RPKM 1.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 11.93 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (24709424..24731846, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (24504426..24526848, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate the role for Gbx1 in development of the spinal cord.
Title: Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development.
Data show that Gbx1 is regionally enriched in the Basal Nucleus of Meynert of mouse brain.
Title: Identification of a set of genes showing regionally enriched expression in the mouse brain.
Combined expression of Lhx7 and Gbx1 plays a role in the development of the cholinergic system of the basal forebrain.
Title: The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system.
expression of Gbx1 suggests that it controls development of a specific subset of GABAergic neurons in the dorsal horn of the spinal cord
Title: The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord.
sequence and expression pattern of Gbx1 in mouse
Title: Isolation and expression of the homeobox gene Gbx1 during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548403

NoName (e-PCR)
- UniSTS:491395

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proprioception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein GBX-1

Names: gastrulation and brain-specific homeobox protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.