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    Ffar3 free fatty acid receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 233080, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ffar3provided by MGI
    Official Full Name
    free fatty acid receptor 3provided by MGI
    Primary source
    MGI:MGI:2685324
    See related
    Ensembl:ENSMUSG00000019429 AllianceGenome:MGI:2685324
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm478; Gpr41
    Summary
    Enables G protein-coupled receptor activity. Involved in several processes, including positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of cytokine production; and regulation of secretion by cell. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of neuronal action potential; and regulation of heart rate by chemical signal. Is active in membrane. Is expressed in several structures, including adrenal gland; gut; peripheral nerve trunk; spleen; and sympathetic nervous system. Orthologous to several human genes including FFAR3 (free fatty acid receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 1.2), large intestine adult (RPKM 0.9) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ffar3 in Genome Data Viewer
    Location:
    7 B1; 7 19.25 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30553755..30555603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30854330..30856178, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18532 Neighboring gene keratinocyte differentiation associated protein Neighboring gene predicted gene, 32236 Neighboring gene free fatty acid receptor 2 Neighboring gene STARR-seq mESC enhancer starr_18534 Neighboring gene STARR-seq mESC enhancer starr_18536 Neighboring gene STARR-positive B cell enhancer ABC_E8162 Neighboring gene free fatty acid receptor 1 Neighboring gene CD22 antigen Neighboring gene STARR-positive B cell enhancer ABC_E6534

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to fatty acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mucosal immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of acute inflammatory response to non-antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of heart rate by chemical signal IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of hormone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of norepinephrine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of peptide hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    free fatty acid receptor 3
    Names
    G-protein coupled receptor 41
    putative G protein-coupled receptor GPR41

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033316.2NP_001028488.1  free fatty acid receptor 3

      See identical proteins and their annotated locations for NP_001028488.1

      Status: PROVISIONAL

      Source sequence(s)
      AK148616
      Consensus CDS
      CCDS21112.1
      UniProtKB/Swiss-Prot
      Q3UFD7
      UniProtKB/TrEMBL
      Q08AU6
      Related
      ENSMUSP00000092163.2, ENSMUST00000094583.2
      Conserved Domains (1) summary
      pfam00001
      Location:28271
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30553755..30555603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)