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    Upk2 uroplakin 2 [ Mus musculus (house mouse) ]

    Gene ID: 22269, updated on 9-Dec-2024

    Summary

    Official Symbol
    Upk2provided by MGI
    Official Full Name
    uroplakin 2provided by MGI
    Primary source
    MGI:MGI:98913
    See related
    Ensembl:ENSMUSG00000041523 AllianceGenome:MGI:98913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UPII
    Summary
    Predicted to be involved in epithelial cell differentiation. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in Meckel's cartilage; bladder; and skeleton. Orthologous to human UPK2 (uroplakin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward bladder adult (RPKM 400.8) See more
    Orthologs
    NEW
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    Genomic context

    See Upk2 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44364012..44366064, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44452715..44454767, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S25 Neighboring gene centrosomal AT-AC splicing factor Neighboring gene STARR-seq mESC enhancer starr_23968 Neighboring gene forkhead box R1 Neighboring gene family with sequence similarity 103, member A1 pseudogene Neighboring gene predicted gene, 22540

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC129164, MGC129165

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in apical plasma membrane urothelial plaque IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    uroplakin-2
    Names
    UP2
    uroplakin II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009476.2NP_033502.2  uroplakin-2 precursor

      See identical proteins and their annotated locations for NP_033502.2

      Status: VALIDATED

      Source sequence(s)
      AC122428, AW491716, BC104260, CX565093
      Consensus CDS
      CCDS23112.1
      UniProtKB/Swiss-Prot
      P38575
      UniProtKB/TrEMBL
      Q3SXK0
      Related
      ENSMUSP00000040481.3, ENSMUST00000047740.4
      Conserved Domains (1) summary
      cl06408
      Location:24184
      UP_III_II; Uroplakin IIIb, IIIa and II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44364012..44366064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)