Mir128-2 microRNA 128-2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir128-2provided by MGI
Official Full Name: microRNA 128-2provided by MGI
Primary source: MGI:MGI:3618709
See related: Ensembl:ENSMUSG00000065441 miRBase:MI0000726; AllianceGenome:MGI:3618709
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn128b; mir-128b; Mirn128-2; mir-128-2
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 9 F3; 9 62.46 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (111947704..111947779, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (112118636..112118711, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA Bmp1 modulates PHF6 expression by sponging miR-128-3p to protect intestinal mucosal in burned mice.
Title: Long noncoding RNA Bmp1 modulates PHF6 expression by sponging miR-128-3p to protect intestinal mucosal in burned mice.
Upregulation of miR-128 Mediates Heart Injury by Activating Wnt/beta-catenin Signaling Pathway in Heart Failure Mice.
Title: Upregulation of miR-128 Mediates Heart Injury by Activating Wnt/β-catenin Signaling Pathway in Heart Failure Mice.
miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons.
Title: miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons.
miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release.
Title: miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release.
miR-128 participates in the pathogenesis of chronic constipation by regulating the p38alpha/M-CSF inflammatory signaling pathway.
Title: miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway.
miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus.
Title: miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus.
miR-128 Regulates Tumor Cell CD47 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer.
Title: miR-128 Regulates Tumor Cell CD47 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer.
Inhibition of microRNA-128-3p attenuates hypercholesterolemia in mouse model.
Title: Inhibition of microRNA-128-3p attenuates hypercholesterolemia in mouse model.
Results suggest that miR-128 serves as a critical regulator of endogenous cardiomyocyte proliferation.
Title: Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.
The mir-128 regulated the immune response of dendritic cells via p38downstream cytokines and miR128 mimic decreased the mRNA expression and secretion of interleukin (IL)6 and IL10 cytokines and increased the level of IL12 in dendritic cells.
Title: miR-128 enhances dendritic cell-mediated anti-tumor immunity via targeting of p38.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Other Names

microRNA 128b
mir 128b
mmu-mir-128-2
mmu-mir-128b

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within long-term synaptic potentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within ossification	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.