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    Spin2c spindlin family, member 2C [ Mus musculus (house mouse) ]

    Gene ID: 278240, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spin2cprovided by MGI
    Official Full Name
    spindlin family, member 2Cprovided by MGI
    Primary source
    MGI:MGI:3605548
    See related
    Ensembl:ENSMUSG00000046550 AllianceGenome:MGI:3605548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spin2; SPIN-2C
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be active in cytosol and nucleoplasm. Is expressed in embryo. Orthologous to human SPIN2A (spindlin family member 2A) and SPIN2B (spindlin family member 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 4.6), genital fat pad adult (RPKM 3.9) and 14 other tissues See more
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    Genomic context

    See Spin2c in Genome Data Viewer
    Location:
    X F3; X 72.38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (152615246..152617239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (153832004..153834243)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene negative regulator of P-body association Neighboring gene SMT3 suppressor of mif two 3 homolog 1, pseudogene (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_48124 Neighboring gene predicted gene, 25895 Neighboring gene spermatogenesis associated multipass transmembrane protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC93001

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in gamete generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    spindlin-2C
    Names
    SPIN-2
    spindlin family, member 2
    spindlin-2
    spindlin-like protein 2
    spindlin-like protein 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005370.2NP_001005370.1  spindlin-2C

      See identical proteins and their annotated locations for NP_001005370.1

      Status: VALIDATED

      Source sequence(s)
      AL831725
      Consensus CDS
      CCDS30485.1
      UniProtKB/Swiss-Prot
      Q6NVE3
      Related
      ENSMUSP00000059499.9, ENSMUST00000049999.9
      Conserved Domains (1) summary
      pfam02513
      Location:4897
      Spin-Ssty; Spin/Ssty Family
    2. NM_001418374.1NP_001405303.1  spindlin-2C

      Status: VALIDATED

      Source sequence(s)
      AL831725
      UniProtKB/Swiss-Prot
      Q6NVE3
    3. NM_001418375.1NP_001405304.1  spindlin-2C

      Status: VALIDATED

      Source sequence(s)
      AL831725
      UniProtKB/Swiss-Prot
      Q6NVE3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      152615246..152617239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)