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    Cyth1 cytohesin 1 [ Mus musculus (house mouse) ]

    Gene ID: 19157, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Cyth1provided by MGI
    Official Full Name
    cytohesin 1provided by MGI
    Primary source
    MGI:MGI:1334257
    See related
    Ensembl:ENSMUSG00000017132 AllianceGenome:MGI:1334257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLM1; CTH-1; CYTIP; Pscd1
    Summary
    Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within establishment of epithelial cell polarity. Located in bicellular tight junction; cytoplasmic side of plasma membrane; and cytosol. Is expressed in nervous system. Orthologous to human CYTH1 (cytohesin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 19.7), frontal lobe adult (RPKM 16.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cyth1 in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118054996..118139452, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118164170..118248616, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene STARR-positive B cell enhancer ABC_E9849 Neighboring gene predicted gene 11738 Neighboring gene STARR-seq mESC enhancer starr_31297 Neighboring gene predicted gene, 38514 Neighboring gene STARR-positive B cell enhancer mm9_chr11:118017777-118018078 Neighboring gene STARR-positive B cell enhancer ABC_E7106 Neighboring gene STARR-positive B cell enhancer ABC_E9850 Neighboring gene VISTA enhancer mm1622 Neighboring gene STARR-positive B cell enhancer ABC_E5309 Neighboring gene STARR-positive B cell enhancer mm9_chr11:118109942-118110243 Neighboring gene STARR-positive B cell enhancer ABC_E9851 Neighboring gene STARR-positive B cell enhancer ABC_E1852 Neighboring gene ubiquitin specific peptidase 36 Neighboring gene STARR-seq mESC enhancer starr_31299 Neighboring gene tissue inhibitor of metalloproteinase 2 Neighboring gene CEP295 N-terminal like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of cDNA encoding mouse cytohesin-1. O'Rourke AM, et al. Immunogenetics, 1998 Oct. PMID 9745014
    2. Cloning and characterization of the promoter of murine cytohesin-1 gene. Goda N, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978522
    3. A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy. Song R, et al. Sci Rep, 2024 Jun 10. PMID 38858421, Free PMC Article
    4. Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells. Bill A, et al. PLoS One, 2012. PMID 22815959, Free PMC Article
    5. Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells. Miyamoto Y, et al. Cell Signal, 2013 Jun. PMID 23517829

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy.
      Title: A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy.
    2. Cytohesin-1 is required for Schwann cell migration and that phosphorylation of cytohesin-1 at the Tyr-382 position is important for migration.
      Title: Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells.
    3. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
      Title: Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
    4. cytohesin inhibition has an antiproliferative effect in gefitinib-resistant lung cancer cells
      Title: Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.
    5. demonstrate an essential role of cytohesin-1/RhoA during ameboid migration in the presence of integrins
      Title: Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA4240

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of epithelial cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytohesin-1
    Names
    PH, SEC7 and coiled-coil domain-containing protein 1
    SEC7 homolog A
    mSec7-1
    pleckstrin homology, Sec7 and coiled-coil domains 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112699.2 → NP_001106169.1  cytohesin-1 isoform 2

      See identical proteins and their annotated locations for NP_001106169.1

      Status: VALIDATED

      Source sequence(s)
      AL591109, AL591204, AL591404
      Consensus CDS
      CCDS48997.1
      UniProtKB/TrEMBL
      Q3T9T9, Q8K3E8
      Related
      ENSMUSP00000017276.8, ENSMUST00000017276.14
      Conserved Domains (2) summary
      cd01252
      Location:259 → 378
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:62 → 244
      Sec7; Sec7 domain

    2. NM_001112700.2 → NP_001106170.1  cytohesin-1 isoform 3

      See identical proteins and their annotated locations for NP_001106170.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AL591109, AL591204
      UniProtKB/TrEMBL
      Q3T9T9, Q3TZ02
      Conserved Domains (4) summary
      cd01252
      Location:261 → 381
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam00169
      Location:265 → 379
      PH; PH domain
      pfam01369
      Location:64 → 246
      Sec7; Sec7 domain
      cl19219
      Location:8 → 90
      DUF342; Protein of unknown function (DUF342)

    3. NM_001378885.1 → NP_001365814.1  cytohesin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591109, AL591204
      UniProtKB/TrEMBL
      B1AQE4, Q3T9T9
      Related
      ENSMUSP00000114792.3, ENSMUST00000151165.3
      Conserved Domains (2) summary
      cd01252
      Location:261 → 380
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:64 → 246
      Sec7; Sec7 domain

    4. NM_001378886.1 → NP_001365815.1  cytohesin-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL591109, AL591204
      UniProtKB/TrEMBL
      Q3T9T9
      Conserved Domains (2) summary
      cd01252
      Location:200 → 319
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:3 → 185
      Sec7; Sec7 domain

    5. NM_001378887.1 → NP_001365816.1  cytohesin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591109, AL591404
      Conserved Domains (1) summary
      pfam01369
      Location:62 → 244
      Sec7; Sec7 domain

    6. NM_001378888.1 → NP_001365817.1  cytohesin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL591109
      Conserved Domains (1) summary
      pfam01369
      Location:3 → 185
      Sec7; Sec7 domain

    7. NM_011180.4 → NP_035310.2  cytohesin-1 isoform 1

      See identical proteins and their annotated locations for NP_035310.2

      Status: VALIDATED

      Source sequence(s)
      AL591109, AL591204, AL591404
      UniProtKB/Swiss-Prot
      O88817, Q76MU4, Q9QX11
      UniProtKB/TrEMBL
      Q3T9T9
      Conserved Domains (2) summary
      cd01252
      Location:259 → 379
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:62 → 244
      Sec7; Sec7 domain

    RNA

    1. NR_166155.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591109, AL591204

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      118054996..118139452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532519.5 → XP_006532582.1  cytohesin-1 isoform X1

      See identical proteins and their annotated locations for XP_006532582.1

      UniProtKB/TrEMBL
      Q3T9T9
      Conserved Domains (2) summary
      cd01252
      Location:200 → 320
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:3 → 185
      Sec7; Sec7 domain

    2. XM_011248805.4 → XP_011247107.1  cytohesin-1 isoform X2

      Conserved Domains (1) summary
      pfam01369
      Location:64 → 246
      Sec7; Sec7 domain

    RNA

    1. XR_003949350.2 RNA Sequence

    2. XR_001779921.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QX11.2 GenPept UniProtKB/Swiss-Prot:Q9QX11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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