Tns2 tensin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tns2provided by MGI
Official Full Name: tensin 2provided by MGI
Primary source: MGI:MGI:2387586
See related: Ensembl:ENSMUSG00000037003 AllianceGenome:MGI:2387586
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: nep; nph; Tenc1; C1-ten
Summary: Predicted to enable several functions, including identical protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Acts upstream of or within several processes, including collagen metabolic process; multicellular organismal-level homeostasis; and response to muscle activity. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in focal adhesion. Is expressed in genitourinary system; hand mesenchyme; hindlimb digit mesenchyme; sensory organ; and skeleton. Used to study Pierson syndrome. Orthologous to human TNS2 (tensin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 60.8), subcutaneous fat pad adult (RPKM 26.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.29 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102006910..102024836)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102098475..102116401)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tensin2 is important for podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier.
Title: Tensin2 is important for podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier.
deficiency causes alteration of actin remodeling and morphological changes in podocytes and subsequent proteinuria
Title: Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing.
Data suggest that Tenc1 (tensin2) contributes to the maintenance of glomerular basement membrane (GBM) structures and that the genetic background influences the severity of nephrotic syndrome.
Title: Tenc1-deficient mice develop glomerular disease in a strain-specific manner.
DISC1-Tensin2 colocalisation was most clearly observed in the Purkinje cells of the mouse cerebellum.
Title: Interaction of DISC1 with the PTB domain of Tensin2.
C1-Ten is a novel protein tyrosine phosphatase (PTPase) of IRS-1 that acts as a mediator to reduce IRS-1 under a catabolic condition, resulting in muscle atrophy. C1-Ten preferentially dephosphorylated Y612 of IRS-1, which accelerated IRS-1 degradation.
Title: C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.
These data descrived the importance of concomitant decreases in podocin, CD2AP and tensin2 during septic acute renal failure-associated proteinuria.
Title: Decreases in podocin, CD2-associated protein (CD2AP) and tensin2 may be involved in albuminuria during septic acute renal failure.
Three strains of the ICGN/Oa mice could be identified by the tensin2 mutation using PCR analysis. The homozygous tensin2 mutation is necessary for the ICGN/Oa mice to develop proteinuria-induced CKD.
Title: Proteinuria-induced chronic kidney disease in the ICGN/Oa mice with a mutation of Tensin2 gene.
Results suggest that tensin2 is involved in expression and extension of nephrin, while tensin2 deficiency may result in proteinuria, associated with the loss of slit integrity.
Title: The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice.
Variant 3 expression enhanced the proliferation rate in culture and in vivo tumorigenicity in nude mice
Title: Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma.
tensin2 gene of the ICGN mouse possessed an 8-nucleotide deletion mutation in exon 18, leading to a frameshift and giving rise to a terminal codon at a premature position.
Title: Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome.

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Phenotypes

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Associated conditions

Description	Tests
nephrosis GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Spontaneous (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal-level homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to muscle activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tensin-2

Names: C1 domain-containing phosphatase and tensin homolog; C1 domain-containing phosphatase and tensin-like protein; tensin-like C1 domain-containing phosphatase

NP_001342565.1

EC 3.1.3.48

NP_001403134.1

EC 3.1.3.48

NP_001403135.1

EC 3.1.3.48

NP_705761.2

EC 3.1.3.48

XP_006520754.1

EC 3.1.3.48

XP_006520756.1

EC 3.1.3.48

XP_030104299.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355636.2 → NP_001342565.1 tensin-2 isoform 2

Status: VALIDATED

Source sequence(s)

AC110512

Consensus CDS

CCDS88852.1

UniProtKB/TrEMBL

A0A2R8VHQ0

Related

ENSMUSP00000041087.10, ENSMUST00000046144.10

Conserved Domains (6) summary

cd09927
Location:1134 → 1247

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00404
Location:189 → 307

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

cd00029
Location:32 → 79

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01213
Location:1271 → 1403

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:297 → 424

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:725 → 1123

Atrophin-1; Atrophin-1 family
NM_001416205.1 → NP_001403134.1 tensin-2 isoform 3

Status: VALIDATED

Source sequence(s)

AC110512

Related

ENSMUSP00000155830.2, ENSMUST00000228958.2
NM_001416206.1 → NP_001403135.1 tensin-2 isoform 4

Status: VALIDATED

Source sequence(s)

AC110512

Related

ENSMUSP00000155309.2, ENSMUST00000230474.2
NM_153533.4 → NP_705761.2 tensin-2 isoform 1

Status: VALIDATED

Source sequence(s)

AC110512

Consensus CDS

CCDS37224.1

UniProtKB/Swiss-Prot

Q3TZ93, Q3UGR8, Q8CGB6, Q8CJ95, Q8R122

UniProtKB/TrEMBL

A0A2R8VHQ0

Related

ENSMUSP00000129146.2, ENSMUST00000169627.9

Conserved Domains (6) summary

cd09927
Location:1127 → 1240

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00404
Location:189 → 307

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

cd00029
Location:32 → 79

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01213
Location:1264 → 1396

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:297 → 424

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

pfam15265
Location:941 → 1115

FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102006910..102024836

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248439.1 → XP_030104299.1 tensin-2 isoform X1

UniProtKB/TrEMBL

A0A2R8VHQ0

Conserved Domains (6) summary

cd09927
Location:1135 → 1248

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

PHA03247
Location:726 → 1124

PHA03247; large tegument protein UL36; Provisional

cd00029
Location:33 → 80

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01213
Location:1272 → 1404

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:298 → 425

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl28904
Location:133 → 291

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006520691.3 → XP_006520754.1 tensin-2 isoform X2

UniProtKB/TrEMBL

A0A2R8VHQ0

Conserved Domains (6) summary

cd09927
Location:1134 → 1247

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

PHA03247
Location:725 → 1123

PHA03247; large tegument protein UL36; Provisional

cd00029
Location:32 → 79

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01213
Location:1271 → 1403

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:297 → 424

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl28904
Location:132 → 290

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006520693.4 → XP_006520756.1 tensin-2 isoform X4

UniProtKB/TrEMBL

A0A2R8VHQ0

Conserved Domains (6) summary

cd09927
Location:1111 → 1224

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

PHA03247
Location:702 → 1100

PHA03247; large tegument protein UL36; Provisional

cd00029
Location:9 → 56

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01213
Location:1248 → 1380

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:274 → 401

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl28904
Location:109 → 267

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily