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    Zc2hc1a zinc finger, C2HC-type containing 1A [ Mus musculus (house mouse) ]

    Gene ID: 67306, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zc2hc1aprovided by MGI
    Official Full Name
    zinc finger, C2HC-type containing 1Aprovided by MGI
    Primary source
    MGI:MGI:1914556
    See related
    Ensembl:ENSMUSG00000043542 AllianceGenome:MGI:1914556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam164a; 3110050N22Rik
    Summary
    Predicted to enable metal ion binding activity. Is expressed in central nervous system; dorsal root ganglion; early conceptus; olfactory epithelium; and oocyte. Orthologous to human ZC2HC1A (zinc finger C2HC-type containing 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 22.4), whole brain E14.5 (RPKM 18.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc2hc1a in Genome Data Viewer
    Location:
    3 A1; 3 2.01 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (7568475..7618908)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (7503415..7553848)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 pseudogene Neighboring gene predicted gene, 23592 Neighboring gene STARR-seq mESC enhancer starr_06837 Neighboring gene STARR-seq mESC enhancer starr_06838 Neighboring gene STARR-seq mESC enhancer starr_06840 Neighboring gene interleukin 7 Neighboring gene predicted gene, 16685 Neighboring gene STARR-seq mESC enhancer starr_06841 Neighboring gene STARR-seq mESC enhancer starr_06842 Neighboring gene STARR-seq mESC enhancer starr_06843 Neighboring gene STARR-seq mESC enhancer starr_06844 Neighboring gene STARR-seq mESC enhancer starr_06846 Neighboring gene STARR-seq mESC enhancer starr_06847 Neighboring gene predicted gene, 29747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    2. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
    3. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90536

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger C2HC domain-containing protein 1A
    Names
    family with sequence similarity 164, member A
    protein FAM164A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428956.1 → NP_001415885.1  zinc finger C2HC domain-containing protein 1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC125373

    2. NM_173181.4 → NP_775273.1  zinc finger C2HC domain-containing protein 1A isoform 1

      See identical proteins and their annotated locations for NP_775273.1

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC125373
      Consensus CDS
      CCDS17230.1
      UniProtKB/Swiss-Prot
      Q3TCP6, Q8BJH1
      Related
      ENSMUSP00000054734.4, ENSMUST00000051064.9
      Conserved Domains (2) summary
      pfam09786
      Location:149 → 293
      CytochromB561_N; Cytochrome B561, N terminal
      pfam13913
      Location:15 → 39
      zf-C2HC_2; zinc-finger of a C2HC-type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      7568475..7618908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530086.1 → XP_006530149.1  zinc finger C2HC domain-containing protein 1A isoform X1

      Conserved Domains (2) summary
      PRK12495
      Location:122 → 234
      PRK12495; hypothetical protein; Provisional
      pfam13913
      Location:15 → 39
      zf-C2HC_2; zinc-finger of a C2HC-type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJH1.1 GenPept UniProtKB/Swiss-Prot:Q8BJH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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