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    Mynn myoneurin [ Mus musculus (house mouse) ]

    Gene ID: 80732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mynnprovided by MGI
    Official Full Name
    myoneurinprovided by MGI
    Primary source
    MGI:MGI:1931415
    See related
    Ensembl:ENSMUSG00000037730 AllianceGenome:MGI:1931415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mynr; SBBIZ1; 2810011C24Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human MYNN (myoneurin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.7), CNS E11.5 (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mynn in Genome Data Viewer
    Location:
    3 A3; 3 14.27 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30656212..30674022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30602087..30619873)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2661 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:30500978-30501161 Neighboring gene actin related protein T3 Neighboring gene nuclear encoded tRNA valine 8 (anticodon AAC) Neighboring gene leucine rich repeat containing 34 Neighboring gene STARR-seq mESC enhancer starr_07297 Neighboring gene leucine-rich repeats and IQ motif containing 4 Neighboring gene STARR-seq mESC enhancer starr_07298 Neighboring gene STARR-seq mESC enhancer starr_07299 Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuromuscular expression of the BTB/POZ and zinc finger protein myoneurin. Cifuentes-Diaz C, et al. Muscle Nerve, 2004 Jan. PMID 14694499
    2. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. Alliel PM, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873615
    3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    4. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myoneurin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289621.1 → NP_001276550.1  myoneurin isoform 2

      See identical proteins and their annotated locations for NP_001276550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC120377, AK014315, BC065084, BF465039
      Consensus CDS
      CCDS79891.1
      UniProtKB/Swiss-Prot
      Q99MD8
      Related
      ENSMUSP00000041034.9, ENSMUST00000047502.9
      Conserved Domains (5) summary
      smart00225
      Location:25 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:304 → 324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:304 → 324
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 115
      BTB; BTB/POZ domain
      pfam13465
      Location:316 → 341
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001289622.1 → NP_001276551.1  myoneurin isoform 3

      See identical proteins and their annotated locations for NP_001276551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC120377, AK163261, BC065084, BF465039
      UniProtKB/Swiss-Prot
      Q99MD8
      Conserved Domains (4) summary
      COG5189
      Location:240 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:190 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:190 → 210
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001289623.1 → NP_001276552.1  myoneurin isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC120377, AK030898, BC065084, BF465039
      UniProtKB/Swiss-Prot
      Q99MD8
      Conserved Domains (3) summary
      sd00017
      Location:190 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:190 → 210
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain

    4. NM_030557.3 → NP_085034.2  myoneurin isoform 1

      See identical proteins and their annotated locations for NP_085034.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC120377, BC065084, BF465039
      Consensus CDS
      CCDS17284.1
      UniProtKB/Swiss-Prot
      Q6P1G7, Q8BT55, Q922I4, Q99MD8, Q9CSA0, Q9CXJ8
      Related
      ENSMUSP00000141951.2, ENSMUST00000192715.6
      Conserved Domains (5) summary
      smart00225
      Location:25 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:304 → 324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:304 → 324
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 115
      BTB; BTB/POZ domain
      pfam13465
      Location:316 → 341
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      30656212..30674022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163419.1 → XP_036019312.1  myoneurin isoform X1

      Conserved Domains (4) summary
      COG5189
      Location:240 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:190 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:190 → 210
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MD8.2 GenPept UniProtKB/Swiss-Prot:Q99MD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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