Cpeb2 cytoplasmic polyadenylation element binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpeb2provided by MGI
Official Full Name: cytoplasmic polyadenylation element binding protein 2provided by MGI
Primary source: MGI:MGI:2442640
See related: Ensembl:ENSMUSG00000039782 AllianceGenome:MGI:2442640
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cpe-bp2; A630055H10Rik
Summary: Enables nucleic acid binding activity and ribosome binding activity. Involved in cellular response to hypoxia; negative regulation of cytoplasmic translation; and regulation of translation at synapse, modulating synaptic transmission. Acts upstream of or within negative regulation of translational elongation. Located in cytoplasm and ribosome. Is active in glutamatergic synapse. Is expressed in central nervous system; early conceptus; and olfactory epithelium. Orthologous to human CPEB2 (cytoplasmic polyadenylation element binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 37.0), CNS E18 (RPKM 7.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 23.65 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (43382692..43447067)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (43225349..43289724)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Title: CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Regulation of Tjp1 mRNA by CPEB2 for tight junction assembly in mouse blastocyst.
Title: Regulation of Tjp1 mRNA by CPEB2 for tight junction assembly in mouse blastocyst.
lncRNA DRAIR is downregulated in diabetic monocytes and modulates the inflammatory phenotype via epigenetic mechanisms.
Title: lncRNA DRAIR is downregulated in diabetic monocytes and modulates the inflammatory phenotype via epigenetic mechanisms.
CPEB2-activated PDGFRalpha mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis.
Title: CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis.
long 3'-UTR Ucp1 mRNA translation activated by CPEB2 is likely conserved and important in humans to produce UCP1 for thermogenesis.
Title: CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.
CPEB2 regulates glutamatergic synapse morphology and plasticity and required for long-term memory. CPEB2 promotes GRASP1 mRNA translation.
Title: CPEB2 Activates GRASP1 mRNA Translation and Promotes AMPA Receptor Surface Expression, Long-Term Potentiation, and Memory.
cholinergic transmission in the knock-out dorsal motor nucleus of vagus was overactivated because knock-out mice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine (i.e., choline acetyltransferase)
Title: Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.
Study reveals new splice isoforms of CPEB2 in mouse brain and its binding to CaMKIIalpha and beta-catenin, both established CPEB1 targets
Title: Characterization of cytoplasmic polyadenylation element binding 2 protein expression and its RNA binding activity.
Data identified an interaction of CPEB (cytoplasmic polyadenylation-element-binding protein) 1 and CPEB2 with the 3'-UTR (untranslated region) of HIF-1alpha mRNA.
Title: Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression.
CPEB2 is expressed postmeiotically in mouse spermatogenesis, suggesting a possible role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids.
Title: CPEB2, a novel putative translational regulator in mouse haploid germ cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cpeb2 (e-PCR), detects polymorphism
- UniSTS:479084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables GTPase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA regulatory element binding translation repressor activity	ISO Inferred from Sequence Orthology more info
enables mRNA regulatory element binding translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables poly-pyrimidine tract binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal large subunit binding	ISO Inferred from Sequence Orthology more info
enables ribosomal large subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal small subunit binding	ISO Inferred from Sequence Orthology more info
enables ribosomal small subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translational elongation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translational elongation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of translational elongation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translation at synapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at synapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 2

Names: CPE-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177379.2 → NP_001170850.1 cytoplasmic polyadenylation element-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC105174

Consensus CDS

CCDS51487.1

UniProtKB/TrEMBL

E9Q5X2

Related

ENSMUSP00000125857.2, ENSMUST00000169035.8

Conserved Domains (4) summary

COG0724
Location:722 → 897

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:735 → 826

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:843 → 923

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:918 → 979

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001368805.1 → NP_001355734.1 cytoplasmic polyadenylation element-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC105174

Conserved Domains (3) summary

cd12724
Location:768 → 859

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:876 → 956

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:951 → 1012

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001368806.1 → NP_001355735.1 cytoplasmic polyadenylation element-binding protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC105174

Consensus CDS

CCDS89916.1

UniProtKB/TrEMBL

E9Q969

Related

ENSMUSP00000130921.3, ENSMUST00000166713.9

Conserved Domains (3) summary

cd12724
Location:765 → 856

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:873 → 953

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:948 → 1009

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001368807.1 → NP_001355736.1 cytoplasmic polyadenylation element-binding protein 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC105174

Conserved Domains (3) summary

cd12724
Location:738 → 829

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:846 → 926

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:921 → 982

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_175937.4 → NP_787951.2 cytoplasmic polyadenylation element-binding protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC105174

UniProtKB/TrEMBL

A0A0H2UH22

Related

ENSMUSP00000109699.4, ENSMUST00000114065.9

Conserved Domains (4) summary

COG0724
Location:744 → 919

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:757 → 848

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:865 → 945

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:940 → 1001

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

43382692..43447067

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503929.3 → XP_006503992.1 cytoplasmic polyadenylation element-binding protein 2 isoform X1

Conserved Domains (3) summary

cd12724
Location:760 → 851

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:868 → 948

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:943 → 1004

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
XM_006503931.3 → XP_006503994.1 cytoplasmic polyadenylation element-binding protein 2 isoform X2

Conserved Domains (3) summary

cd12724
Location:730 → 821

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:838 → 918

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:913 → 974

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
XM_006503932.4 → XP_006503995.1 cytoplasmic polyadenylation element-binding protein 2 isoform X3

Conserved Domains (3) summary

cd12724
Location:727 → 818

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:835 → 915

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:910 → 971

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain